Alvaro Lorente-Macias
Overview
Explore the profile of Alvaro Lorente-Macias including associated specialties, affiliations and a list of published articles.
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12
Citations
160
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Recent Articles
1.
Garcia-Peiro J, Ortega-Liebana M, Adam C, Lorente-Macias A, Travnickova J, Patton E, et al.
Angew Chem Int Ed Engl
. 2025 Jan;
e202424037.
PMID: 39813113
Beyond their classical role as cytotoxics, Platinum (Pt) coordination complexes recently joined the selected group of transition metals capable of performing bioorthogonal reactions in living environments. To minimize their reactivity...
2.
Ayala-Aguilera C, Ge Y, Lorente-Macias A, Jones B, Adam C, Carragher N, et al.
RSC Med Chem
. 2024 Nov;
PMID: 39493221
Oesophageal cancer (OC) is one of the leading causes of cancer-related deaths worldwide. Due in part to its high heterogeneity, OC prognosis remains poor despite the introduction of targeted and...
3.
Hernandez-Moran B, Taylor G, Lorente-Macias A, Wood A
Dis Model Mech
. 2024 Apr;
17(4).
PMID: 38666498
Degron tagging allows proteins of interest to be rapidly degraded, in a reversible and tuneable manner, in response to a chemical stimulus. This provides numerous opportunities for understanding disease mechanisms,...
4.
Baillache D, Valero T, Lorente-Macias A, Bennett D, Elliott R, Carragher N, et al.
RSC Med Chem
. 2023 Dec;
14(12):2611-2624.
PMID: 38099057
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer in adults, with an average life expectancy under treatment of approx. 15 months. GBM is characterised by a complex...
5.
Klug D, Tse E, Silva D, Cao Y, Charman S, Chauhan J, et al.
ACS Infect Dis
. 2023 Nov;
9(12):2423-2435.
PMID: 37991879
Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it challenging to generate much-needed medicines. As...
6.
Smer-Barreto V, Quintanilla A, Elliott R, Dawson J, Sun J, Campa V, et al.
Nat Commun
. 2023 Jun;
14(1):3445.
PMID: 37301862
Cellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection. Despite growing interest in targeted elimination of senescent cells,...
7.
Ayala-Aguilera C, Valero T, Lorente-Macias A, Baillache D, Croke S, Unciti-Broceta A
J Med Chem
. 2021 Oct;
65(2):1047-1131.
PMID: 34624192
The central role of dysregulated kinase activity in the etiology of progressive disorders, including cancer, has fostered incremental efforts on drug discovery programs over the past 40 years. As a...
8.
Martinez-Peinado N, Lorente-Macias A, Garcia-Salguero A, Cortes-Serra N, Fenollar-Collado A, Ros-Lucas A, et al.
Pharmaceuticals (Basel)
. 2021 Aug;
14(7).
PMID: 34358064
Malaria and Chagas disease, caused by spp. and parasites, remain important global health problems. Available treatments for those diseases present several limitations, such as lack of efficacy, toxic side effects,...
9.
Lorente-Macias A, Ianez I, Jimenez-Lopez M, Benitez-Quesada M, Torres-Rusillo S, Diaz-Mochon J, et al.
Arch Pharm (Weinheim)
. 2021 Jun;
354(10):e2100095.
PMID: 34128249
Purines are ubiquitous structures in cell biology involved in a multitude of cellular processes, because of which substituted purines and analogs are considered excellent scaffolds in drug design. In this...
10.
Wang C, Lorente-Macias A, Wells C, Pickett J, Picado A, Zuercher W, et al.
RSC Med Chem
. 2021 May;
12(1):129-136.
PMID: 34046605
RIOK2 is an understudied kinase associated with a variety of human cancers including non-small cell lung cancer and glioblastoma. No potent, selective, and cell-active chemical probe currently exists for RIOK2....