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Alok Swaroop

Explore the profile of Alok Swaroop including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 231
Followers 0
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Recent Articles
1.
Swaroop A, Yue F
Mol Cell . 2025 Jan; 85(1):1-2. PMID: 39753104
In this issue of Molecular Cell, Gambi, Boccalatte, Hernaez, et al. apply multiomics followed by genetic engineering to define then characterize epigenetic hubs that regulate processes crucial for T-ALL and...
2.
Abaza Y, Winer E, Guru Murthy G, Shallis R, Matthews A, Badar T, et al.
Am J Hematol . 2024 Feb; 99(4):606-614. PMID: 38342997
Venetoclax (VEN) combined with hypomethylating agents (HMAs) is the standard of care for the treatment of patients with newly diagnosed acute myeloid leukemia (AML) unfit for intensive chemotherapy. To date,...
3.
Ruan J, Zain J, Palmer B, Jovanovic B, Mi X, Swaroop A, et al.
Blood Adv . 2023 Jun; 7(19):5771-5779. PMID: 37327113
Peripheral T-cell lymphomas (PTCLs) are associated with poor prognosis when treated with cytotoxic chemotherapy. We report the findings of a phase 2 study evaluating a chemotherapy-free combination of romidepsin plus...
4.
Swaroop A, Saleiro D, Platanias L
Bioessays . 2023 Jan; 45(3):e2200203. PMID: 36642848
Interferons (IFNs) are a diverse group of cytokines whose potent antitumor effects have piqued the interest of scientists for decades. Some of the most sustained clinical accomplishments have been in...
5.
Li J, Hlavka-Zhang J, Shrimp J, Piper C, Dupere-Richer D, Roth J, et al.
Cancer Discov . 2021 Aug; 12(1):186-203. PMID: 34417224
Mutations in epigenetic regulators are common in relapsed pediatric acute lymphoblastic leukemia (ALL). Here, we uncovered the mechanism underlying the relapse of ALL driven by an activating mutation of the...
6.
Swaroop A, Oyer J, Will C, Huang X, Yu W, Troche C, et al.
Oncogene . 2018 Sep; 38(5):671-686. PMID: 30171259
NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL),...
7.
Bennett R, Swaroop A, Troche C, Licht J
Cold Spring Harb Perspect Med . 2017 Feb; 7(6). PMID: 28193767
The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1). These enzymes recognize and catalyze methylation of histone...
8.
Vo A, Swaroop A, Liu Y, Norris Z, Shavit J
PLoS One . 2013 Oct; 8(9):e74682. PMID: 24098662
Cessation of bleeding after trauma is a necessary evolutionary vertebrate adaption for survival. One of the major pathways regulating response to hemorrhage is the coagulation cascade, which ends with the...
9.
Ng L, Lu A, Swaroop A, Sharlin D, Swaroop A, Forrest D
J Neurosci . 2011 Aug; 31(31):11118-25. PMID: 21813673
The typical mammalian visual system is based upon three photoreceptor types: rods for dim light vision and two types of cones (M and S) for color vision in daylight. However,...