Christine M Will
Overview
Explore the profile of Christine M Will including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
319
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0
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Recent Articles
1.
Li J, Hlavka-Zhang J, Shrimp J, Piper C, Dupere-Richer D, Roth J, et al.
Cancer Discov
. 2021 Aug;
12(1):186-203.
PMID: 34417224
Mutations in epigenetic regulators are common in relapsed pediatric acute lymphoblastic leukemia (ALL). Here, we uncovered the mechanism underlying the relapse of ALL driven by an activating mutation of the...
2.
Bennett R, Bele A, Small E, Will C, Nabet B, Oyer J, et al.
Cancer Discov
. 2019 Jul;
9(10):1438-1451.
PMID: 31337617
By examination of the cancer genomics database, we identified a new set of mutations in core histones that frequently recur in cancer patient samples and are predicted to disrupt nucleosome...
3.
Swaroop A, Oyer J, Will C, Huang X, Yu W, Troche C, et al.
Oncogene
. 2018 Sep;
38(5):671-686.
PMID: 30171259
NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL),...
4.
Ezponda T, Dupere-Richer D, Will C, Small E, Varghese N, Patel T, et al.
Cell Rep
. 2017 Oct;
21(3):628-640.
PMID: 29045832
Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX leads to...
5.
Nabet B, Broin P, Reyes J, Shieh K, Lin C, Will C, et al.
Cell Rep
. 2015 Aug;
12(8):1300-13.
PMID: 26279576
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRas(G12V)...
6.
Popovic R, Martinez-Garcia E, Giannopoulou E, Zhang Q, Zhang Q, Ezponda T, et al.
PLoS Genet
. 2014 Sep;
10(9):e1004566.
PMID: 25188243
Overexpression of the histone methyltransferase MMSET in t(4;14)+ multiple myeloma patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma. MMSET catalyzes dimethylation of...