Almudena Pino-Angeles
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Explore the profile of Almudena Pino-Angeles including associated specialties, affiliations and a list of published articles.
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15
Citations
154
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Recent Articles
1.
Garcia-Alberca J, de Rojas I, Sanchez-Mejias E, Garrido-Martin D, Gonzalez-Palma L, Jimenez S, et al.
J Alzheimers Dis
. 2024 Mar;
98(2):601-618.
PMID: 38427484
Background: Microglial dysfunction plays a causative role in Alzheimer's disease (AD) pathogenesis. Here we focus on a germline insertion/deletion variant mapping SIRPβ1, a surface receptor that triggers amyloid-β(Aβ) phagocytosis via...
2.
Ding T, Karlov D, Pino-Angeles A, Tikhonova I
J Chem Inf Model
. 2022 Sep;
62(19):4736-4747.
PMID: 36178787
Allosteric modulators are called promising candidates in G protein-coupled receptor (GPCR) drug development by displaying subtype selectivity and more specific receptor modulation. Among the allosteric sites known to date, cavities...
3.
Moya-Garcia A, Pino-Angeles A, Sanchez-Jimenez F, Urdiales J, Medina M
Biomolecules
. 2021 Apr;
11(3).
PMID: 33799732
Histamine is a highly pleiotropic biogenic amine involved in key physiological processes including neurotransmission, immune response, nutrition, and cell growth and differentiation. Its effects, sometimes contradictory, are mediated by at...
4.
Sepehri A, PeBenito L, Pino-Angeles A, Lazaridis T
Biophys J
. 2020 Mar;
118(8):1901-1913.
PMID: 32183940
Pore formation by membrane-active peptides, naturally encountered in innate immunity and infection, could have important medical and technological applications. Recently, the well-studied lytic peptide melittin has formed the basis for...
5.
Pino-Angeles A, Lazaridis T
Biophys J
. 2018 Jun;
114(12):2865-2874.
PMID: 29925023
Melittin is a short cationic peptide that exerts cytolytic effects on bacterial and eukaryotic cells. Experiments suggest that in zwitterionic membranes, melittin forms transmembrane toroidal pores supported by four to...
6.
Lipkin R, Pino-Angeles A, Lazaridis T
J Phys Chem B
. 2017 Sep;
121(39):9126-9140.
PMID: 28879767
Protegrin-1 is an 18-residue β-hairpin antimicrobial peptide (AMP) that has been suggested to form transmembrane β-barrels in biological membranes. However, alternative structures have also been proposed. Here, we performed multimicrosecond,...
7.
Garcia-Vilas J, Pino-Angeles A, Martinez-Poveda B, Quesada A, Medina M
Cancer Lett
. 2016 Nov;
385:1-11.
PMID: 27816491
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting...
8.
Sanchez-Jimenez F, Pino-Angeles A, Rodriguez-Lopez R, Morales M, Urdiales J
Pharmacol Res
. 2016 Nov;
114:90-102.
PMID: 27769832
Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. The enzymes share...
9.
Pino-Angeles A, Leveritt 3rd J, Lazaridis T
PLoS Comput Biol
. 2016 Jan;
12(1):e1004570.
PMID: 26727376
Magainin 2 and PGLa are among the best-studied cationic antimicrobial peptides. They bind preferentially to negatively charged membranes and apparently cause their disruption by the formation of transmembrane pores, whose...
10.
Leveritt 3rd J, Pino-Angeles A, Lazaridis T
Biophys J
. 2015 May;
108(10):2424-2426.
PMID: 25992720
Melittin has been reported to form toroidal pores under certain conditions, but the atomic-resolution structure of these pores is unknown. A 9-μs all-atom molecular-dynamics simulation starting from a closely packed...