Allison L Bayer
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Explore the profile of Allison L Bayer including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1088
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Recent Articles
1.
Fotino C, Molano R, Ben Nasr M, Umland O, Fraker C, Ulissi U, et al.
Diabetes
. 2023 Aug;
72(11):1641-1651.
PMID: 37625134
Article Highlights:
2.
Shapiro M, Peters L, Brown M, Cabello-Kindelan C, Posgai A, Bayer A, et al.
J Immunol
. 2023 Aug;
211(7):1108-1122.
PMID: 37594278
IL-2 has been proposed to restore tolerance via regulatory T cell (Treg) expansion in autoimmunity, yet off-target effects necessitate identification of a combinatorial approach allowing for lower IL-2 dosing. We...
3.
Zisi Tegou F, Velluto D, Stock A, Fitzgerald S, Stealey S, Zustiak S, et al.
J Control Release
. 2022 Jun;
348:499-517.
PMID: 35691500
Type-I Diabetes (T1D) is caused by defective immunotolerance mechanisms enabling autoreactive T cells to escape regulation in lymphoid organs and destroy insulin-producing β-cells in the pancreas, leading to insulin dependence....
4.
Li Y, Frei A, Labrada I, Rong Y, Liang J, Samojlik M, et al.
Front Immunol
. 2021 Jun;
12:653088.
PMID: 34122410
Allogeneic islet transplantation is a promising cell-based therapy for Type 1 Diabetes (T1D). The long-term efficacy of this approach, however, is impaired by allorejection. Current clinical practice relies on long-term...
5.
Li Y, Frei A, Yang E, Labrada-Miravet I, Sun C, Rong Y, et al.
Biomaterials
. 2020 Jun;
256:120182.
PMID: 32599358
The curative potential of non-autologous cellular therapy is hindered by the requirement of anti-rejection therapy. Cellular encapsulation within nondegradable biomaterials has the potential to inhibit immune rejection, but the efficacy...
6.
Cabello-Kindelan C, Mackey S, Sands A, Rodriguez J, Vazquez C, Pugliese A, et al.
Diabetes
. 2019 Nov;
69(2):215-227.
PMID: 31712320
Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4Foxp3 regulatory T cells (T) are a key cell population capable of facilitating durable immune...
7.
Gonzalez Badillo F, Zisi Tegou F, Abreu M, Masina R, Sha D, Najjar M, et al.
Diabetes
. 2019 Aug;
68(10):1990-2003.
PMID: 31371518
Tumors induce tolerance toward their antigens by producing the chemokine CCL21, leading to the formation of tertiary lymphoid organs (TLOs). Ins2-CCL21 transgenic, nonobese diabetic (NOD) mice express CCL21 in pancreatic...
8.
Dwyer C, Bayer A, Fotino C, Yu L, Cabello-Kindelan C, Ward N, et al.
Sci Signal
. 2017 Dec;
10(510).
PMID: 29259102
The cytokine interleukin-2 (IL-2) is critical for the functions of regulatory T cells (T). The contribution of polymorphisms in the gene encoding the IL-2 receptor α subunit (), which are...
9.
The Folate Cycle As a Cause of Natural Killer Cell Dysfunction and Viral Etiology in Type 1 Diabetes
Bayer A, Fraker C
Front Endocrinol (Lausanne)
. 2017 Dec;
8:315.
PMID: 29218028
The folate pathway is critical to proper cellular function and metabolism. It is responsible for multiple functions, including energy (ATP) production, methylation reactions for DNA and protein synthesis and the...
10.
Manzoli V, Villa C, Bayer A, Morales L, Molano R, Torrente Y, et al.
Am J Transplant
. 2017 Oct;
18(3):590-603.
PMID: 29068143
Islet encapsulation may allow transplantation without immunosuppression, but thus far islets in large microcapsules transplanted in the peritoneal cavity have failed to reverse diabetes in humans. We showed that islet...