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Allison Kraus

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Articles 41
Citations 1186
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Recent Articles
1.
Browne D, Smirnov D, Coughlin D, Peng I, Standke H, Kim Y, et al.
Nat Commun . 2025 Feb; 16(1):1851. PMID: 39984462
Tau neurofibrillary tangles (NFTs) in the presence of amyloid-β (Aβ) plaques are required for the diagnosis of Alzheimer's Disease (AD) and closely track with cognitive impairment, yet cognitively normal aged...
2.
Aguilar-Calvo P, Malik A, Sandoval D, Barback C, Orru C, Standke H, et al.
PLoS Pathog . 2023 Sep; 19(9):e1011487. PMID: 37747931
Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet...
3.
Manca M, Standke H, Browne D, Huntley M, Thomas O, Orru C, et al.
Acta Neuropathol . 2023 May; 146(1):31-50. PMID: 37154939
Tau neurofibrillary tangles are a hallmark of Alzheimer's disease neuropathological change. However, it remains largely unclear how distinctive Alzheimer's disease tau seeds (i.e. 3R/4R) correlate with histological indicators of tau...
4.
Foster K, Manca M, McClure K, Koivula P, Trojanowski J, Havas D, et al.
Alzheimers Dement . 2023 Apr; 19(10):4662-4674. PMID: 37002928
Background: The cis-conformer of tau phosphorylated at threonine-231 (cis-pT231 tau) is hypothesized to contribute to tauopathies. PNT001 is a humanized, monoclonal antibody that recognizes cis-pT231 tau. PNT001 was characterized to...
5.
Hoyt F, Alam P, Artikis E, Schwartz C, Hughson A, Race B, et al.
PLoS Pathog . 2022 Nov; 18(11):e1010947. PMID: 36342968
Prion strains in a given type of mammalian host are distinguished by differences in clinical presentation, neuropathological lesions, survival time, and characteristics of the infecting prion protein (PrP) assemblies. Near-atomic...
6.
Coughlin D, Goodwill V, Standke H, Kim Y, Coley N, Pizzo D, et al.
Acta Neuropathol . 2022 Aug; 144(4):789-792. PMID: 35980456
No abstract available.
7.
Hoyt F, Standke H, Artikis E, Schwartz C, Hansen B, Li K, et al.
Nat Commun . 2022 Jul; 13(1):4005. PMID: 35831291
Little is known about the structural basis of prion strains. Here we provide a high (3.0 Å) resolution cryo-electron microscopy-based structure of infectious brain-derived fibrils of the mouse anchorless RML...
8.
Caughey B, Standke H, Artikis E, Hoyt F, Kraus A
PLoS Pathog . 2022 Jun; 18(6):e1010594. PMID: 35771767
No abstract available.
9.
Artikis E, Kraus A, Caughey B
J Biol Chem . 2022 Jun; 298(8):102181. PMID: 35752366
The structures of prion protein (PrP)-based mammalian prions have long been elusive. However, cryo-EM has begun to reveal the near-atomic resolution structures of fully infectious ex vivo mammalian prion fibrils...
10.
Standke H, Kraus A
Cell Tissue Res . 2022 Mar; 392(1):323-335. PMID: 35258712
The accumulation of misfolded proteins as amyloid fibrils in the brain is characteristic of most neurodegenerative disorders. These misfolded proteins are capable of self-amplifying through protein seeding mechanisms, leading to...