Allison D Fryer
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Explore the profile of Allison D Fryer including associated specialties, affiliations and a list of published articles.
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74
Citations
1545
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Recent Articles
11.
Calco G, Proskocil B, Jacoby D, Fryer A, Nie Z
Am J Physiol Lung Cell Mol Physiol
. 2021 Oct;
321(6):L1105-L1118.
PMID: 34668415
Increased insulin is associated with obesity-related airway hyperreactivity and asthma. We tested whether the use of metformin, an antidiabetic drug used to reduce insulin resistance, can reduce circulating insulin, thereby...
12.
Drake M, Cook M, Fryer A, Jacoby D, Scott G
Front Physiol
. 2021 Sep;
12:720538.
PMID: 34557110
Airway sensory nerves detect a wide variety of chemical and mechanical stimuli, and relay signals to circuits within the brainstem that regulate breathing, cough, and bronchoconstriction. Recent advances in histological...
13.
Proskocil B, Wai K, Lebold K, Norgard M, Michaelis K, De La Torre U, et al.
J Neuroinflammation
. 2021 Sep;
18(1):209.
PMID: 34530852
Background: Toll-like receptor 7 (TLR7) is an innate immune receptor that detects viral single-stranded RNA and triggers the production of proinflammatory cytokines and type 1 interferons in immune cells. TLR7...
14.
Drake M, Fryer A, Jacoby D
J Allergy Clin Immunol Pract
. 2021 Jun;
9(6):2539-2540.
PMID: 34112482
No abstract available.
15.
Proskocil B, Fryer A, Jacoby D, Nie Z
Am J Physiol Lung Cell Mol Physiol
. 2021 May;
321(1):L236-L247.
PMID: 34009030
Obesity-related asthma often presents with more severe symptoms than non-obesity-related asthma and responds poorly to current treatments. Both insulin resistance and hyperinsulinemia are common in obesity. We have shown that...
16.
Pincus A, Fryer A, Jacoby D
Neurosci Lett
. 2021 Mar;
751:135795.
PMID: 33667601
Neural changes underly hyperresponsiveness in asthma and other airway diseases. Afferent sensory nerves, nerves within the brainstem, and efferent parasympathetic nerves all contribute to airway hyperresponsiveness. Inflammation plays a critical...
17.
Shapiro C, Proskocil B, Oppegard L, Blum E, Kappel N, Chang C, et al.
Am J Respir Crit Care Med
. 2020 Aug;
203(3):348-355.
PMID: 32809840
Chronic cough is characterized by frequent urges to cough and a heightened sensitivity to inhaled irritants. Airway sensory nerves trigger cough. We hypothesized that sensory nerve density is increased in...
18.
Marsh B, Fryer A, Jacoby D, Drake M
Am J Physiol Lung Cell Mol Physiol
. 2020 Apr;
318(5):L943-L952.
PMID: 32233794
Transient receptor potential ankyrin-1 (TRPA1) is a ligand-gated cation channel that responds to endogenous and exogenous irritants. TRPA1 is expressed on multiple cell types throughout the lungs, but previous studies...
19.
Calco G, Fryer A, Nie Z
J Leukoc Biol
. 2020 Mar;
108(1):123-128.
PMID: 32170879
Obesity affects more than 650 million adults worldwide and is a major risk factor for a variety of serious comorbidities. The prevalence of obesity has tripled in the past forty...
20.
Pincus A, Adhikary S, Lebold K, Fryer A, Jacoby D
Am J Respir Cell Mol Biol
. 2020 Jan;
62(4):423-429.
PMID: 31899655
Dysregulation of airway nerves leads to airway hyperreactivity, a hallmark of asthma. Although changes to nerve density and phenotype have been described in asthma, the relevance of these changes to...