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Allen Nguyen

Explore the profile of Allen Nguyen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 26
Citations 559
Followers 0
Related Specialties
General Medicine
Biochemistry
Biology
Top 10 Co-Authors
Jacqueline M McBride
Wyne P Lee
Laura DeForge
Abhijit Mazumder
Min Xu
Jason A Hackney
Judy Young
Zhonghua Lin
Mercedesz Balazs
Donghong Yan
Published In
Open Forum Infect Dis
BMC Biotechnol
Antimicrob Agents Chemother
Pediatr Pulmonol
Proteomics Clin Appl
Affiliations
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Recent Articles
1.
Structure-activity relationship studies and pharmacological evaluation of 4-phenylthiazoles as dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors
Yuan C, Tsang A, Berumen M, Rodriguez A, Yun F, Mesic A, et al.
Bioorg Med Chem . 2025 Feb; 121:118112. PMID: 39983408
Forty-two 4-phenylthiazole analogs, organized in two libraries 4a-u and 6a-u, were prepared and biologically evaluated in human fatty acid amide hydrolase (FAAH), and human, rat and mouse soluble epoxide hydrolase...
2.
Comprehensive profiling of the human fecal proteome from IBD patients with DIA-MS enables evaluation of disease-relevant proteins
Harder B, Lekkerkerker A, Casavant E, Hackney J, Nguyen A, McBride J, et al.
Proteomics Clin Appl . 2024 Mar; 18(5):e2300075. PMID: 38552248
Purpose: Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), is characterized by chronic gastrointestinal inflammation. A high unmet need exists for noninvasive biomarkers in IBD...
3.
First-in-human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC-2394, in healthy volunteers
Tang F, Kunder R, Chu T, Hains A, Nguyen A, McBride J, et al.
Clin Transl Sci . 2023 Jun; 16(9):1653-1666. PMID: 37350225
Inappropriate and chronic activation of the cytosolic NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome, a key component of innate immunity, likely underlies several inflammatory diseases, including coronary artery disease....
4.
Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis
Jha D, Al-Taie Z, Krek A, Toghi Eshghi S, Fantou A, Laurent T, et al.
bioRxiv . 2023 Jun; PMID: 37333091
Ulcerative colitis (UC) is an idiopathic chronic inflammatory disease of the colon with sharply rising global prevalence. Dysfunctional epithelial compartment (EC) dynamics are implicated in UC pathogenesis although EC-specific studies...
5.
A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of the Monoclonal Antibody MHAA4549A in Patients With Acute Uncomplicated Influenza A Infection
Lim J, Dar S, Venter D, Horcajada J, Kulkarni P, Nguyen A, et al.
Open Forum Infect Dis . 2022 Feb; 9(2):ofab630. PMID: 35106315
Background: MHAA4549A, a human monoclonal antibody targeting the influenza A hemagglutinin stalk, neutralizes influenza A virus in animal and human volunteer challenge studies. We investigated the safety and tolerability, efficacy,...
6.
Surfactant protein D is a biomarker of influenza-related pediatric lung injury
Chakrabarti A, Nguyen A, Newhams M, Ohlson M, Yang X, Ulufatu S, et al.
Pediatr Pulmonol . 2021 Nov; 57(2):519-528. PMID: 34842360
Background: Biomarkers that can risk-stratify children with influenza virus lower respiratory infection may identify patients for targeted intervention. Early elevation of alveolar-related proteins in the bloodstream in these patients could...
7.
Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease
Dai B, Hackney J, Ichikawa R, Nguyen A, Elstrott J, Orozco L, et al.
Cell Rep Med . 2021 Sep; 2(8):100381. PMID: 34467254
Anti-integrins are therapeutically effective for inflammatory bowel disease, yet the relative contribution of α4β7 and αEβ7 to gut lymphocyte trafficking is not fully elucidated. Here, we evaluate the effect of...
8.
Early Amplified Respiratory Bioactive Lipid Response Is Associated With Worse Outcomes in Pediatric Influenza-Related Respiratory Failure
Anania V, Randolph A, Yang X, Nguyen A, Newhams M, Mathews W, et al.
Open Forum Infect Dis . 2020 May; 7(5):ofaa122. PMID: 32420403
Background: Biomarkers are needed for early identification of patients at risk of severe complications from influenza infection, including prolonged respiratory failure and death. Eicosanoids are bioactive lipid mediators with pro-...
9.
A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of MHAA4549A, a Monoclonal Antibody, plus Oseltamivir in Patients Hospitalized with Severe Influenza A Virus Infection
Lim J, Nilsson A, Silverman M, Assy N, Kulkarni P, McBride J, et al.
Antimicrob Agents Chemother . 2020 May; 64(7). PMID: 32393496
For patients hospitalized with severe influenza A virus infection, morbidity and mortality remain high. MHAA4549A, a human monoclonal antibody targeting the influenza A virus hemagglutinin stalk, has demonstrated pharmacological activity...
10.
Haplotyping the Vitis collinear core genome with rhAmpSeq improves marker transferability in a diverse genus
Zou C, Karn A, Reisch B, Nguyen A, Sun Y, Bao Y, et al.
Nat Commun . 2020 Jan; 11(1):413. PMID: 31964885
Transferable DNA markers are essential for breeding and genetics. Grapevine (Vitis) breeders utilize disease resistance alleles from congeneric species ~20 million years divergent, but existing Vitis marker platforms have cross-species...