Allegra M Lord
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Explore the profile of Allegra M Lord including associated specialties, affiliations and a list of published articles.
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12
Citations
2189
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Recent Articles
1.
Wojtowicz E, Mistry J, Uzun V, Hellmich C, Scoones A, Chin D, et al.
Genome Biol
. 2023 Jun;
24(1):152.
PMID: 37370129
Background: Platelets and erythrocytes constitute over 95% of all hematopoietic stem cell output. However, the clonal dynamics of HSC contribution to these lineages remains largely unexplored. Results: We use lentiviral...
2.
Cahill T, Sun X, Ravaud C, Villa Del Campo C, Klaourakis K, Lupu I, et al.
Development
. 2021 Jan;
148(3).
PMID: 33462113
Macrophages are components of the innate immune system with key roles in tissue inflammation and repair. It is now evident that macrophages also support organogenesis, but few studies have characterized...
3.
Carrelha J, Meng Y, Kettyle L, Luis T, Norfo R, Alcolea V, et al.
Nature
. 2018 Jan;
554(7690):106-111.
PMID: 29298288
Rare multipotent haematopoietic stem cells (HSCs) in adult bone marrow with extensive self-renewal potential can efficiently replenish all myeloid and lymphoid blood cells, securing long-term multilineage reconstitution after physiological and...
4.
Obeng E, Chappell R, Seiler M, Chen M, Campagna D, Schmidt P, et al.
Cancer Cell
. 2016 Sep;
30(3):404-417.
PMID: 27622333
More than 80% of patients with the refractory anemia with ring sideroblasts subtype of myelodysplastic syndrome (MDS) have mutations in Splicing Factor 3B, Subunit 1 (SF3B1). We generated a conditional...
5.
Schneider R, Adema V, Heckl D, Jaras M, Mallo M, Lord A, et al.
Cancer Cell
. 2014 Sep;
26(4):509-20.
PMID: 25242043
The casein kinase 1A1 gene (CSNK1A1) is a putative tumor suppressor gene located in the common deleted region for del(5q) myelodysplastic syndrome (MDS). We generated a murine model with conditional...
6.
North T, Babu I, Vedder L, Lord A, Wishnok J, Tannenbaum S, et al.
Proc Natl Acad Sci U S A
. 2010 Sep;
107(40):17315-20.
PMID: 20855591
Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the United States. The only available treatment, N-acetylcysteine (NAC), has a limited time window of efficacy,...
7.
Mullally A, Lane S, Ball B, Megerdichian C, Okabe R, Al-Shahrour F, et al.
Cancer Cell
. 2010 Jun;
17(6):584-96.
PMID: 20541703
We report a Jak2V617F knockin mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we demonstrate that the hematopoietic stem cell (HSC) compartment...
8.
North T, Goessling W, Peeters M, Li P, Ceol C, Lord A, et al.
Cell
. 2009 May;
137(4):736-48.
PMID: 19450519
During vertebrate embryogenesis, hematopoietic stem cells (HSCs) arise in the aorta-gonads-mesonephros (AGM) region. We report here that blood flow is a conserved regulator of HSC formation. In zebrafish, chemical blood...
9.
Goessling W, North T, Loewer S, Lord A, Lee S, Stoick-Cooper C, et al.
Cell
. 2009 Mar;
136(6):1136-47.
PMID: 19303855
Interactions between developmental signaling pathways govern the formation and function of stem cells. Prostaglandin (PG) E2 regulates vertebrate hematopoietic stem cells (HSC). Similarly, the Wnt signaling pathway controls HSC self-renewal...
10.
Goessling W, North T, Lord A, Ceol C, Lee S, Weidinger G, et al.
Dev Biol
. 2008 Jul;
320(1):161-74.
PMID: 18585699
Developmental signaling pathways hold the keys to unlocking the promise of adult tissue regeneration, and to inhibiting carcinogenesis. Patients with mutations in the Adenomatous Polyposis Coli (APC) gene are at...