Alistair N Boettiger
Overview
Explore the profile of Alistair N Boettiger including associated specialties, affiliations and a list of published articles.
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31
Citations
3774
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Recent Articles
1.
Jensen C, Chen L, Swigut T, Crocker O, Yao D, Bassik M, et al.
Mol Cell
. 2024 Dec;
85(2):347-361.e7.
PMID: 39626660
Although critical for tuning the timing and level of transcription, enhancer communication with distal promoters is not well understood. Here, we bypass the need for sequence-specific transcription factors (TFs) and...
2.
Kraft K, Murphy S, Jones M, Shi Q, Bhargava-Shah A, Luong C, et al.
bioRxiv
. 2024 Sep;
PMID: 39282372
Extrachromosomal DNA (ecDNA) is a hallmark of aggressive cancer, contributing to both oncogene amplification and tumor heterogeneity. Here, we used Hi-C, super-resolution imaging, and long-read sequencing to explore the nuclear...
3.
Jensen C, Chen L, Swigut T, Crocker O, Yao D, Bassik M, et al.
bioRxiv
. 2024 Jul;
PMID: 39071420
While critical for tuning the timing and level of transcription, enhancer communication with distal promoters is not well understood. Here we bypass the need for sequence-specific transcription factors and recruit...
4.
Le D, Hafner A, Gaddam S, Wang K, Boettiger A
bioRxiv
. 2024 May;
PMID: 38766104
Regulation of gene expression hinges on the interplay between enhancers and promoters, traditionally explored through pairwise analyses. Recent advancements in mapping genome folding, like GAM, SPRITE, and multi-contact Hi-C, have...
5.
Hung T, Kingsley D, Boettiger A
Nat Genet
. 2024 Jan;
56(2):306-314.
PMID: 38238628
Although promoters and their enhancers are frequently contained within a topologically associating domain (TAD), some developmentally important genes have their promoter and enhancers within different TADs. Hypotheses about molecular mechanisms...
6.
Fujimori T, Rios-Martinez C, Thurm A, Hinks M, Doughty B, Sinha J, et al.
bioRxiv
. 2023 Oct;
PMID: 37873344
Repressive chromatin modifications are thought to compact chromatin to silence transcription. However, it is unclear how chromatin structure changes during silencing and epigenetic memory formation. We measured gene expression and...
7.
Dutta S, Ghosh A, Boettiger A, Spakowitz A
Biophys J
. 2023 Aug;
122(17):3532-3540.
PMID: 37542372
Chromosomal dynamics plays a central role in a number of critical biological processes, such as transcriptional regulation, genetic recombination, and DNA replication. However, visualization of chromatin is generally limited to...
8.
Hafner A, Park M, Berger S, Murphy S, Nora E, Boettiger A
Mol Cell
. 2023 May;
83(9):1377-1392.e6.
PMID: 37146570
Although population-level analyses revealed significant roles for CTCF and cohesin in mammalian genome organization, their contributions at the single-cell level remain incompletely understood. Here, we used a super-resolution microscopy approach...
9.
Kraft K, Yost K, Murphy S, Magg A, Long Y, Corces M, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(22):e2201883119.
PMID: 35617427
Polycomb-group proteins play critical roles in gene silencing through the deposition of histone H3 lysine 27 trimethylation (H3K27me3) and chromatin compaction. This process is essential for embryonic stem cell (ESC)...
10.
Xiao J, Hafner A, Boettiger A
Elife
. 2021 Jul;
10.
PMID: 34240703
Animal genomes are organized into topologically associated domains (TADs). TADs are thought to contribute to gene regulation by facilitating enhancer-promoter (E-P) contacts within a TAD and preventing these contacts across...