Alistair J Ingram
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Explore the profile of Alistair J Ingram including associated specialties, affiliations and a list of published articles.
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32
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1058
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Recent Articles
21.
Wu D, Peng F, Zhang B, Ingram A, Kelly D, Gilbert R, et al.
J Am Soc Nephrol
. 2009 Feb;
20(3):554-66.
PMID: 19211711
Accumulation of glomerular matrix is a hallmark of diabetic nephropathy. The serine/threonine kinase Akt mediates glucose-induced upregulation of collagen I in mesangial cells through transactivation of the EGF receptor (EGFR)....
22.
Peng F, Zhang B, Wu D, Ingram A, Gao B, Krepinsky J
Am J Physiol Renal Physiol
. 2008 Apr;
295(1):F153-64.
PMID: 18434385
Glomerular sclerosis of diverse etiologies is characterized by mesangial matrix accumulation, with transforming growth factor-beta (TGFbeta) an important pathogenic factor. The GTPase RhoA mediates TGFbeta-induced matrix accumulation in some settings....
23.
Peng F, Wu D, Gao B, Ingram A, Zhang B, Chorneyko K, et al.
Diabetes
. 2008 Mar;
57(6):1683-92.
PMID: 18356410
Objective: Accumulation of glomerular matrix proteins is central to the pathogenesis of diabetic nephropathy, with resident mesangial cells (MCs) known to upregulate matrix protein synthesis in response to high glucose....
24.
Zhang B, Peng F, Wu D, Ingram A, Gao B, Krepinsky J
Cell Signal
. 2007 Apr;
19(8):1690-700.
PMID: 17446044
Increased glomerular hydrostatic pressure is an important determinant of glomerulosclerosis and can be modeled in vitro by exposure of mesangial cells (MC) to cyclic mechanical strain. We have recently shown...
25.
Peng F, Wu D, Ingram A, Zhang B, Gao B, Krepinsky J
J Am Soc Nephrol
. 2006 Nov;
18(1):189-98.
PMID: 17121865
Increased intraglomerular pressure is an important hemodynamic determinant of glomerulosclerosis and can be modeled in vitro by exposing mesangial cells to cyclic mechanical strain. A previous study showed that RhoA...
26.
Krepinsky J, Li Y, Chang Y, Liu L, Peng F, Wu D, et al.
J Am Soc Nephrol
. 2005 Apr;
16(6):1661-72.
PMID: 15814837
Increased glomerular hydrostatic pressure is an important determinant of glomerulosclerosis and can be modeled by in vitro exposure of mesangial cells to cyclic mechanical strain. Stretched mesangial cells increase extracellular...
27.
Krepinsky J, Li Y, Tang D, Liu L, Scholey J, Ingram A
Cell Signal
. 2004 Nov;
17(3):311-20.
PMID: 15567062
Glomerular capillary hypertension is a determinant of glomerulosclerosis and is modelled in vitro by exposure of mesangial cells to cyclic mechanical strain. In response to strain, Erk is activated and...
28.
Ingram A, Krepinsky J, James L, Austin R, Tang D, Salapatek A, et al.
Kidney Int
. 2004 Jul;
66(2):733-45.
PMID: 15253728
Background: Alteration in mesangial cell function is central to the progression of glomerular disease in numerous models of chronic renal failure (CRF). Animal models of chronic glomerular disease are characterized...
29.
Krepinsky J, Ingram A, Tang D, Wu D, Liu L, Scholey J
J Am Soc Nephrol
. 2003 Oct;
14(11):2790-800.
PMID: 14569089
Glomerular capillary hypertension is an important determinant of glomerulosclerosis in rats with subtotal renal ablation. Dietary supplementation with L-arginine increases renal nitric oxide (NO) production and limits glomerular injury in...
30.
Crowther M, Clase C, Margetts P, Julian J, Lambert K, Sneath D, et al.
J Am Soc Nephrol
. 2002 Aug;
13(9):2331-7.
PMID: 12191977
Polytetrafluoroethylene (PTFE) dialysis grafts in patients with end-stage renal disease (ESRD) are prone to thrombotic failure. The objective of this multicenter, randomized, double-blind, placebo-controlled clinical trial was to determine if...