Alison A Humbles
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Explore the profile of Alison A Humbles including associated specialties, affiliations and a list of published articles.
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42
Citations
2686
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Recent Articles
1.
Strickson S, Houslay K, Negri V, Ohne Y, Ottosson T, Dodd R, et al.
Eur Respir J
. 2023 Jul;
62(3).
PMID: 37442582
Background: Epithelial damage, repair and remodelling are critical features of chronic airway diseases including chronic obstructive pulmonary disease (COPD). Interleukin (IL)-33 released from damaged airway epithelia causes inflammation its receptor,...
2.
Dagher R, Fogel P, Wang J, Soussan D, Chiang C, Kearley J, et al.
PLoS One
. 2022 Dec;
17(12):e0277357.
PMID: 36480517
Objective: Novel biomarkers related to main clinical hallmarks of Chronic obstructive pulmonary disease (COPD), a heterogeneous disorder with pulmonary and extra-pulmonary manifestations, were investigated by profiling the serum levels of...
3.
Dagher R, Kumar V, Copenhaver A, Gallagher S, Ghaedi M, Boyd J, et al.
Eur Respir J
. 2021 Jul;
59(3).
PMID: 34289975
Background: Benralizumab is a humanised, anti-interleukin-5 receptor α monoclonal antibody with anti-eosinophilic activity. Lack of fucose (afucosylation) increases its affinity to CD16a and significantly enhances antibody-dependent cell-mediated cytotoxicity by natural...
4.
Dagher R, Copenhaver A, Besnard V, Berlin A, Hamidi F, Maret M, et al.
Nat Commun
. 2020 Sep;
11(1):4786.
PMID: 32963227
Evidence points to an indispensable function of macrophages in tissue regeneration, yet the underlying molecular mechanisms remain elusive. Here we demonstrate a protective function for the IL-33-ST2 axis in bronchial...
5.
Silver J, Humbles A, Ohne Y
Methods Mol Biol
. 2020 Mar;
2121:115-127.
PMID: 32147791
Innate lymphoid cells (ILCs) are lymphocytes with critical roles in homeostasis, inflammation, and immunity to pathogens. ILCs are rare relative to other immune cell populations and are primarily defined by...
6.
Jogdand P, Siddhuraj P, Mori M, Sanden C, Jonsson J, Walls A, et al.
Eur Respir J
. 2020 Feb;
55(5).
PMID: 32060064
Although elevated blood or sputum eosinophils are present in many patients with COPD, uncertainties remain regarding the anatomical distribution pattern of lung-infiltrating eosinophils. Basophils have remained virtually unexplored in COPD....
7.
Bernink J, Ohne Y, Teunissen M, Wang J, Wu J, Krabbendam L, et al.
Nat Immunol
. 2019 Nov;
21(1):101.
PMID: 31723260
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Bernink J, Ohne Y, Teunissen M, Wang J, Wu J, Krabbendam L, et al.
Nat Immunol
. 2019 Jul;
20(8):992-1003.
PMID: 31263279
Here we identify a group 2 innate lymphoid cell (ILC2) subpopulation that can convert into interleukin-17 (IL-17)-producing NKp44 ILC3-like cells. c-Kit and CCR6 define this ILC2 subpopulation that exhibits ILC3...
9.
Magnen M, Gueugnon F, Petit-Courty A, Baranek T, Sizaret D, Brewah Y, et al.
Am J Physiol Lung Cell Mol Physiol
. 2019 Mar;
316(6):L1127-L1140.
PMID: 30908937
Host cell proteases are involved in influenza pathogenesis. We examined the role of tissue kallikrein 1 (KLK1) by comparing wild-type (WT) and KLK1-deficient mice infected with influenza H3N2 virus. The...
10.
Andersson C, Shikhagaie M, Mori M, Al-Garawi A, Reed J, Humbles A, et al.
ERJ Open Res
. 2018 Nov;
4(4).
PMID: 30480000
Viral infections predispose to the development of childhood asthma, a disease associated with increased lung mast cells (MCs). This study investigated whether viral lower respiratory tract infections (LRTIs) can already...