Alisa K Manning
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Explore the profile of Alisa K Manning including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Noordam R, Wang W, Nagarajan P, Wang H, Brown M, Bentley A, et al.
medRxiv
. 2024 Sep;
PMID: 39281768
We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify novel genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets. We...
12.
Willems S, Ng N, Fernandez J, Fine R, Wheeler E, Wessel J, et al.
Wellcome Open Res
. 2024 Sep;
8():483.
PMID: 39280063
Background: Genome-wide association studies for glycemic traits have identified hundreds of loci associated with these biomarkers of glucose homeostasis. Despite this success, the challenge remains to link variant associations to...
13.
Francis M, Westerman K, Manning A, Ye K
PLoS Genet
. 2024 Jul;
20(7):e1011288.
PMID: 38990837
We examined the associations of vegetarianism with metabolic biomarkers using traditional and genetic epidemiology. First, we addressed inconsistencies in self-reported vegetarianism among UK Biobank participants by utilizing data from two...
14.
Choi J, Lee H, Kuang A, Huerta-Chagoya A, Scholtens D, Choi D, et al.
Diabetes Care
. 2024 Jun;
47(9):1622-1629.
PMID: 38940851
Objective: Women with a history of gestational diabetes mellitus (GDM) are at increased risk of developing type 2 diabetes (T2D). It remains unclear whether genetic information improves prediction of incident...
15.
de Vries P, Conomos M, Singh K, Nicholson C, Jain D, Hasbani N, et al.
Nat Cardiovasc Res
. 2024 May;
2(12):1159-1172.
PMID: 38817323
Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study (GWAS) of CAC in...
16.
Smith K, Deutsch A, McGrail C, Kim H, Hsu S, Huerta-Chagoya A, et al.
Nat Med
. 2024 May;
30(7):2091.
PMID: 38760590
No abstract available.
17.
Nagarajan P, Winkler T, Bentley A, Miller C, Kraja A, Schwander K, et al.
medRxiv
. 2024 Mar;
PMID: 38496537
Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we...
18.
Smith K, Deutsch A, McGrail C, Kim H, Hsu S, Huerta-Chagoya A, et al.
Nat Med
. 2024 Mar;
30(4):1065-1074.
PMID: 38443691
Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for which the underlying biological mechanisms are not fully understood. In this study, we identified multi-ancestry T2D genetic...
19.
Westerman K, Kilpelainen T, Sevilla-Gonzalez M, Connelly M, Wood A, Tsai M, et al.
medRxiv
. 2024 Feb;
PMID: 38313294
Large-scale gene-environment interaction (GxE) discovery efforts often involve compromises in the definition of outcomes and choice of covariates for the sake of data harmonization and statistical power. Consequently, refinement of...
20.
Pham D, Westerman K, Pan C, Chen L, Srinivasan S, Isganaitis E, et al.
Bioinformatics
. 2023 Dec;
39(12).
PMID: 38039147
Motivation: statistics from genome-wide association studies enable many valuable downstream analyses that are more efficient than individual-level data analysis while also reducing privacy concerns. As growing sample sizes enable better-powered...