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Alice S Chen-Plotkin

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Articles 76
Citations 4147
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Recent Articles
1.
Zhang H, Kargilis D, Tropea T, Robinson J, Shen J, Brody E, et al.
Ann Clin Transl Neurol . 2025 Mar; PMID: 40053464
Objective: Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome-wide association studies (GWAS)...
2.
Gilboa T, Ter-Ovanesyan D, Wang S, Whiteman S, Kannarkat G, Church G, et al.
Proc Natl Acad Sci U S A . 2024 Oct; 121(45):e2408949121. PMID: 39475636
Extracellular vesicles (EVs) are released by all cells and hold great promise as a class of biomarkers. This promise has led to increased interest in measuring EV proteins from both...
3.
Kannarkat G, Zack R, Skrinak R, Morley J, Davila-Rivera R, Arezoumandan S, et al.
Res Sq . 2024 Oct; PMID: 39372921
Aggregation of misfolded α-synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBD), including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Evidence exists for...
4.
Gallagher J, Gochanour C, Caspell-Garcia C, Dobkin R, Aarsland D, Alcalay R, et al.
Neurology . 2024 Aug; 103(5):e209699. PMID: 39110916
Background And Objectives: It is widely cited that dementia occurs in up to 80% of patients with Parkinson disease (PD), but studies reporting such high rates were published over two...
5.
Kannarkat G, Zack R, Skrinak R, Morley J, Davila-Rivera R, Arezoumandan S, et al.
bioRxiv . 2024 May; PMID: 38765963
Spread and aggregation of misfolded α-synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBD), including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). While...
6.
Tropea T, Hartstone W, Amari N, Baum D, Rick J, Suh E, et al.
NPJ Parkinsons Dis . 2024 May; 10(1):97. PMID: 38702337
Observational studies in Parkinson's disease (PD) deeply characterize relatively small numbers of participants. The Molecular Integration in Neurological Diagnosis Initiative seeks to characterize molecular and clinical features of every PD...
7.
Brody E, Seo Y, Suh E, Amari N, Hartstone W, Skrinak R, et al.
Mov Disord . 2024 Apr; 39(6):1065-1070. PMID: 38610104
Background: The GPNMB single-nucleotide polymorphism rs199347 and GBA1 variants both associate with Lewy body disorder (LBD) risk. GPNMB encodes glycoprotein nonmetastatic melanoma protein B (GPNMB), a biomarker for GBA1-associated Gaucher's...
8.
Cousins K, Irwin D, Tropea T, Rhodes E, Phillips J, Chen-Plotkin A, et al.
Neurology . 2024 Feb; 102(4):e208033. PMID: 38306599
Background And Objectives: In Parkinson disease (PD), Alzheimer disease (AD) copathology is common and clinically relevant. However, the longitudinal progression of AD CSF biomarkers-β-amyloid 1-42 (Aβ), phosphorylated tau 181 (p-tau),...
9.
Arezoumandan S, Cousins K, Ohm D, Lowe M, Chen M, Gee J, et al.
Ann Clin Transl Neurol . 2024 Jan; 11(3):673-685. PMID: 38263854
Objective: Alzheimer's disease neuropathologic change and alpha-synucleinopathy commonly co-exist and contribute to the clinical heterogeneity of dementia. Here, we examined tau epitopes marking various stages of tangle maturation to test...
10.
Diaz-Ortiz M, Jain N, Gallagher M, Posavi M, Unger T, Chen-Plotkin A
Bio Protoc . 2023 Oct; 13(19):e4832. PMID: 37817908
Many single nucleotide polymorphisms (SNPs) identified by genome-wide association studies exert their effects on disease risk as expression quantitative trait loci (eQTL) via allele-specific expression (ASE). While databases for probing...