Alice Ballone
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Explore the profile of Alice Ballone including associated specialties, affiliations and a list of published articles.
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10
Citations
95
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Recent Articles
1.
Ballone A, Picarazzi F, Prosser C, Davis J, Ottmann C, Mori M
J Chem Inf Model
. 2020 Nov;
60(12):6555-6565.
PMID: 33138374
The exploration of the druggability of certain protein-protein interactions (PPIs) still remains a challenging task in drug discovery. Here, we present a case study using the 14-3-3-PPI, showing how small...
2.
Ballone A, Lau R, Zweipfenning F, Ottmann C
Acta Crystallogr F Struct Biol Commun
. 2020 Oct;
76(Pt 10):501-507.
PMID: 33006579
Interactions between a protein and a peptide motif of its protein partner are prevalent in nature. Often, a protein also has multiple interaction partners. X-ray protein crystallography is commonly used...
3.
Menzel J, Kownatzki-Danger D, Tokar S, Ballone A, Unthan-Fechner K, Kilisch M, et al.
Sci Signal
. 2020 Sep;
13(647).
PMID: 32873725
The cardiac membrane protein phospholamban (PLN) is targeted by protein kinase A (PKA) at Ser and by Ca/calmodulin-dependent protein kinase II (CaMKII) at Thr β-Adrenergic stimulation and PKA-dependent phosphorylation of...
4.
Dainese E, Oddi S, Simonetti M, Sabatucci A, Angelucci C, Ballone A, et al.
Sci Rep
. 2020 Apr;
10(1):5903.
PMID: 32235840
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
5.
Wolter M, Lentini Santo D, Herman P, Ballone A, Centorrino F, Obsil T, et al.
ACS Omega
. 2020 Mar;
5(10):5380-5388.
PMID: 32201828
Inflammatory responses mediated by the transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) play key roles in immunity, autoimmune diseases, and cancer. NF-κB is directly regulated through...
6.
Dainese E, Oddi S, Simonetti M, Sabatucci A, Angelucci C, Ballone A, et al.
Sci Rep
. 2020 Feb;
10(1):2292.
PMID: 32041998
Fatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that in vivo controls content and biological activity of N-arachidonoylethanolamine (AEA) and other relevant bioactive lipids termed endocannabinoids. Parallel orientation...
7.
Ballone A, Centorrino F, Wolter M, Ottmann C
Data Brief
. 2018 Sep;
19:1683-1687.
PMID: 30229043
Activation of Ras-MAPK signaling regulates essential cellular functions; its aberration leads to irregular cell proliferation and differentiation (i.e. pancreatic cancer). Previously, it was revealed that the formation of the complex...
8.
Ballone A, Centorrino F, Ottmann C
Molecules
. 2018 Jun;
23(6).
PMID: 29890630
In recent years, targeting the complex network of protein⁻protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic...
9.
Centorrino F, Ballone A, Wolter M, Ottmann C
FEBS Lett
. 2018 Feb;
592(7):1211-1220.
PMID: 29473952
The ubiquitin-specific protease 8 (USP8)/14-3-3 protein-protein interaction has recently been shown to exert a significant role in the pathogenesis of Cushing's disease (CD). USP8 is a deubiquitinase that prevents epidermal...
10.
Ballone A, Centorrino F, Wolter M, Ottmann C
J Struct Biol
. 2018 Feb;
202(3):210-215.
PMID: 29408703
The deviant Ras activation machinery is found in approximately 30% of all human cancers. SOS1 is an important protagonist of this pathway that plays a key-role in aberrant cell proliferation...