Madita Wolter
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Explore the profile of Madita Wolter including associated specialties, affiliations and a list of published articles.
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16
Citations
227
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Recent Articles
1.
During J, Wolter M, Toplak J, Torres C, Dybkov O, Fokkens T, et al.
Nat Struct Mol Biol
. 2024 Feb;
31(2):364-377.
PMID: 38332367
Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system by selecting substrates and decorating them with distinct ubiquitin signals. However, structure determination of the underlying, specific E3-substrate complexes...
2.
Wu Q, Centorrino F, Guillory X, Wolter M, Ottmann C, Cossar P, et al.
Chembiochem
. 2023 Oct;
25(1):e202300636.
PMID: 37902676
Protein-protein interaction (PPI) modulation is a promising approach in drug discovery with the potential to expand the 'druggable' proteome and develop new therapeutic strategies. While there have been significant advancements...
3.
Genet S, Wolfs J, Vu C, Wolter M, Broeren M, van Dongen J, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2023 Apr;
1223:123701.
PMID: 37086508
Neuron-specific enolase (NSE) is a promising small-cell lung cancer (SCLC) biomarker composed of αγ and γγ isozyme dimers. As the conventional immunoassays are prone to interferences and cannot differentiate between...
4.
Stevers L, Wolter M, Carlile G, Macdonald D, Richard L, Gielkens F, et al.
Nat Commun
. 2022 Jun;
13(1):3586.
PMID: 35739107
Impaired activity of the chloride channel CFTR is the cause of cystic fibrosis. 14-3-3 proteins have been shown to stabilize CFTR and increase its biogenesis and activity. Here, we report...
5.
Srdanovic S, Wolter M, Trinh C, Ottmann C, Warriner S, Wilson A
FEBS J
. 2022 Mar;
289(17):5341-5358.
PMID: 35286747
p53 plays a critical role in regulating diverse biological processes: DNA repair, cell cycle arrest, apoptosis and senescence. The p53 pathway has therefore served as the focus of multiple drug-discovery...
6.
Wolter M, Valenti D, Cossar P, Hristeva S, Levy L, Genski T, et al.
J Med Chem
. 2021 Jun;
64(12):8423-8436.
PMID: 34076416
Protein-protein modulation has emerged as a proven approach to drug discovery. While significant progress has been gained in developing protein-protein interaction (PPI) inhibitors, the orthogonal approach of PPI stabilization lacks...
7.
Cossar P, Wolter M, van Dijck L, Valenti D, Levy L, Ottmann C, et al.
J Am Chem Soc
. 2021 May;
143(22):8454-8464.
PMID: 34047554
The stabilization of protein complexes has emerged as a promising modality, expanding the number of entry points for novel therapeutic intervention. Targeting proteins that mediate protein-protein interactions (PPIs), such as...
8.
Wolter M, Valenti D, Cossar P, Levy L, Hristeva S, Genski T, et al.
Angew Chem Int Ed Engl
. 2020 Aug;
59(48):21520-21524.
PMID: 32816380
Small-molecule stabilization of protein-protein interactions (PPIs) is a promising concept in drug discovery, however the question how to identify or design chemical starting points in a "bottom-up" approach is largely...
9.
Guillory X, Wolter M, Leysen S, Neves J, Kuusk A, Genet S, et al.
J Med Chem
. 2020 Jun;
63(13):6694-6707.
PMID: 32501690
Stabilization of protein-protein interactions (PPIs) holds great potential for therapeutic agents, as illustrated by the successful drugs rapamycin and lenalidomide. However, how such interface-binding molecules can be created in a...
10.
Wolter M, de Vink P, Neves J, Srdanovic S, Higuchi Y, Kato N, et al.
J Am Chem Soc
. 2020 Jun;
142(27):11772-11783.
PMID: 32501683
Natural compounds are an important class of potent drug molecules including some retrospectively found to act as stabilizers of protein-protein interactions (PPIs). However, the design of synthetic PPI stabilizers remains...