Alfredo Ramirez
Overview
Explore the profile of Alfredo Ramirez including associated specialties, affiliations and a list of published articles.
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201
Citations
7999
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Recent Articles
1.
Takalo M, Jeskanen H, Rolova T, Kervinen I, Hellen M, Heikkinen S, et al.
J Neuroinflammation
. 2025 Mar;
22(1):64.
PMID: 40038760
Background: Phospholipase C gamma 2, proline 522 to arginine (PLCγ2-P522R) is a protective variant that reduces the risk of Alzheimer's disease (AD). Recently, it was shown to mitigate β-amyloid pathology...
2.
Sampatakakis S, Mourtzi N, Hatzimanolis A, Koutsis G, Charisis S, Gkelmpesi I, et al.
Int J Mol Sci
. 2025 Feb;
26(3).
PMID: 39940679
In the present study, we investigated the association of genetic predisposition with specific dimensions of dementia pathophysiology for global and domain-specific cognitive decline in older adults. The sample was drawn...
3.
Haag L, Lancini E, Yakupov R, Ziegler G, Yi Y, Lusebrink F, et al.
Brain Commun
. 2025 Feb;
7(1):fcaf031.
PMID: 39926613
Neurotransmitter systems of noradrenaline, dopamine, serotonin and acetylcholine are implicated in cognitive functions such as memory, learning and attention and are known to be altered in neurodegenerative diseases like Alzheimer's...
4.
Liampas I, Siokas V, Mourtzi N, Charisis S, Sampatakakis S, Foukarakis I, et al.
Geriatrics (Basel)
. 2025 Jan;
10(1.
PMID: 39846584
Background: There is a paucity of evidence on the association between genetic propensity for hippocampal atrophy with cognitive outcomes. Therefore, we examined the relationship of the polygenic risk score for...
5.
Charisis S, Mourtzi N, Scott M, Ntanasi E, Mamalaki E, Hatzimanolis A, et al.
J Prev Alzheimers Dis
. 2025 Jan;
12(1):100018.
PMID: 39800457
Importance: Aging is accompanied by immune dysregulation, which has been implicated in Alzheimer's disease (AD) pathogenesis. Individuals who are genetically predisposed to elevated levels of proinflammatory mediators might be at...
6.
Puerta R, Cano A, Garcia-Gonzalez P, Garcia-Gutierrez F, Capdevila M, de Rojas I, et al.
Int J Mol Sci
. 2025 Jan;
26(1.
PMID: 39796148
High-throughput proteomic platforms are crucial to identify novel Alzheimer's disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan 7k) and antibody-based (Olink...
7.
Blomeke L, Rehn F, Pils M, Kraemer-Schulien V, Cousin A, Kutzsche J, et al.
Commun Med (Lond)
. 2024 Dec;
4(1):262.
PMID: 39658587
Background: Quantification of Amyloid beta (Aβ) oligomers in plasma enables early diagnosis of Alzheimer's Disease (AD) and improves our understanding of underlying pathologies. However, quantification necessitates an extremely sensitive and...
8.
Heneka M, van der Flier W, Jessen F, Hoozemanns J, Thal D, Boche D, et al.
Nat Rev Immunol
. 2024 Dec;
PMID: 39653749
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines...
9.
Le Borgne J, Gomez L, Heikkinen S, Amin N, Ahmad S, Choi S, et al.
Mol Psychiatry
. 2024 Dec;
PMID: 39633006
Due to methodological reasons, the X-chromosome has not been featured in the major genome-wide association studies on Alzheimer's Disease (AD). To address this and better characterize the genetic landscape of...
10.
Choe K, Ali M, Lardenoije R, Riemens R, Pishva E, Bickel H, et al.
Alzheimers Res Ther
. 2024 Nov;
16(1):259.
PMID: 39616392
Background: Neurodegenerative disorders, including Alzheimer's disease (AD), have been linked to alterations in tryptophan (TRP) metabolism. However, no studies to date have systematically explored changes in the TRP pathway at...