Alfred S Lewin
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Explore the profile of Alfred S Lewin including associated specialties, affiliations and a list of published articles.
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123
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3851
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Recent Articles
1.
Ridley R, Amontree A, Lewin A, Ildefonso C
Adv Exp Med Biol
. 2025 Feb;
1468:375-379.
PMID: 39930225
Retinal pigmented epithelial (RPE) cells have critical functions in the retina. These cells rely heavily on their mitochondria to generate energy, offer metabolites for biosynthesis through the TCA cycle, regulate...
2.
Ahmed C, Johnson H, Lewin A
Front Immunol
. 2024 Aug;
15:1416181.
PMID: 39104531
Several blinding diseases affecting the retina and optic nerve are exacerbated by or caused by dysregulated inflammation and oxidative stress. These diseases include uveitis, age related macular degeneration, diabetic retinopathy...
3.
Ahmed C, Patel A, Johnson H, Ildefonso C, Lewin A
Mol Vis
. 2024 Jan;
29:338-356.
PMID: 38264613
Purpose: Inflammation and oxidative stress contribute to age-related macular degeneration (AMD) and other retinal diseases. We tested a cell-penetrating peptide from the kinase inhibitory region of an intracellular checkpoint inhibitor...
4.
Biswal M, Paulson R, Vichare R, Lewin A
Antioxidants (Basel)
. 2023 Dec;
12(12).
PMID: 38136248
Chronic oxidative stress impairs the normal functioning of the retinal pigment epithelium (RPE), leading to atrophy of this cell layer in cases of advance age-related macular degeneration (AMD). The purpose...
5.
Ridley R, Bowman B, Lee J, Walsh E, Massengill M, Lewin A, et al.
bioRxiv
. 2023 Feb;
PMID: 36798403
The advanced form of AMD, geographic atrophy, is associated with increased RPE oxidative stress and chronic inflammation. Here we evaluated the effects of delivering an anti-inflammatory viral gene by an...
6.
Ahmed C, Massengill M, Ildefonso C, Jalligampala A, Zhu P, Li H, et al.
Vision Res
. 2023 Feb;
206:108189.
PMID: 36773475
Autosomal dominant retinitis pigmentosa (adRP) is frequently caused by mutations in RHO, the gene for rhodopsin. In previous experiments in dogs with the T4R mutation in RHO, an AAV2/5 vector...
7.
Lewin A, Smith W
Cold Spring Harb Perspect Med
. 2022 Aug;
PMID: 35940643
Mutations in , the gene for rhodopsin, account for a large fraction of autosomal-dominant retinitis pigmentosa (adRP). Patients fall into two clinical classes, those with early onset, pan retinal photoreceptor...
8.
Ahmed C, Grams T, Bloom D, Johnson H, Lewin A
Front Immunol
. 2022 Jul;
13:902956.
PMID: 35799776
Suppressors of Cytokine Signaling (SOCS) are intracellular proteins that negatively regulate the induction of cytokines. Amongst these, SOCS1 and SOCS3 are particularly involved in inhibition of various interferons. Several viruses...
9.
Choudhary M, Ildefonso C, Lewin A, Malek G
J Ocul Pharmacol Ther
. 2022 Apr;
38(5):359-371.
PMID: 35446130
The NLRP3 inflammasome, a cytoplasmic signal transduction complex that regulates inflammation, has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of visual impairment in industrialized...
10.
Massengill M, Lewin A
Int Ophthalmol Clin
. 2021 Sep;
61(4):79-96.
PMID: 34584046
No abstract available.