Alfred Lautwein
Overview
Explore the profile of Alfred Lautwein including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
137
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0
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Recent Articles
1.
Diesinger T, Lautwein A, Buko V, Belonovskaya E, Lukivskaya O, Naruta E, et al.
Physiol Rep
. 2021 Mar;
9(6):e14795.
PMID: 33769703
Cytochrome P450 2E1 (CYP2E1)-associated reactive oxygen species production plays an important role in the development and progression of inflammatory liver diseases such as alcoholic steatohepatitis. We developed two new inhibitors...
2.
Diesinger T, Lautwein A, Bergler S, Buckert D, Renz C, Dvorsky R, et al.
Can J Gastroenterol Hepatol
. 2021 Feb;
2021:8854432.
PMID: 33604316
Cytochrome P450 2E1 (CYP2E1) is a key target protein in the development of alcoholic and nonalcoholic fatty liver disease (FLD). The pathophysiological correlate is the massive production of reactive oxygen...
3.
Diesinger T, Buko V, Lautwein A, Dvorsky R, Belonovskaya E, Lukivskaya O, et al.
PLoS One
. 2020 Jul;
15(7):e0235990.
PMID: 32701948
Background And Aims: Alcoholic steatohepatitis (ASH)-the inflammation of fatty liver-is caused by chronic alcohol consumption and represents one of the leading chronic liver diseases in Western Countries. ASH can lead...
4.
Burster T, Beck A, Tolosa E, Marin-Esteban V, Rotzschke O, Falk K, et al.
J Immunol
. 2004 Apr;
172(9):5495-503.
PMID: 15100291
The asparagine-specific endoprotease (AEP) controls lysosomal processing of the potential autoantigen myelin basic protein (MBP) by human B lymphoblastoid cells, a feature implicated in the immunopathogenesis of multiple sclerosis. In...
5.
Lautwein A, Kraus M, Reich M, Burster T, Brandenburg J, Overkleeft H, et al.
J Leukoc Biol
. 2004 Feb;
75(5):844-55.
PMID: 14966190
Endocytic proteolysis represents a major functional component of the major histocompatibility complex class II antigen-presentation machinery. Although transport and assembly of class II molecules in the endocytic compartment are well...
6.
Tolosa E, Li W, Yasuda Y, Wienhold W, Denzin L, Lautwein A, et al.
J Clin Invest
. 2003 Aug;
112(4):517-26.
PMID: 12925692
Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S...
7.
Wiendl H, Lautwein A, Mitsdorffer M, Krause S, Erfurth S, Wienhold W, et al.
J Neuroimmunol
. 2003 May;
138(1-2):132-43.
PMID: 12742663
The immunological properties of muscle cells are of critical importance for both the pathogenesis of inflammatory muscle disorders as well as for understanding and controlling novel therapeutic strategies. Muscle cells...
8.
Greiner A, Lautwein A, Overkleeft H, Weber E, Driessen C
J Leukoc Biol
. 2003 Jan;
73(2):235-42.
PMID: 12554800
Cathepsins (Cat) in antigen presenting cells (APC) control antigen processing as well as major histocompatibility complex class II transport and function. The set of active Cat and the subcellular architecture...
9.
Lautwein A, Burster T, Lennon-Dumenil A, Overkleeft H, Weber E, Kalbacher H, et al.
Eur J Immunol
. 2002 Nov;
32(12):3348-57.
PMID: 12432565
Proteolysis by endocytic cysteine proteases is a central element of the antigen-presentation machinery in dendritic cells (DC). It controls the generation of immunogenic peptides, guides the transit of both MHC...