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Alexey Epanchintsev

Explore the profile of Alexey Epanchintsev including associated specialties, affiliations and a list of published articles. Areas
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Articles 13
Citations 1172
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Recent Articles
1.
Ziegler N, Bader E, Epanchintsev A, Margerie D, Kannt A, Schmoll D
J Biol Chem . 2021 Jan; 295(51):17659-17671. PMID: 33454005
AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a wide range of proteins to maintain cellular homeostasis. AMPK consists of three subunits: α, β, and...
2.
Epanchintsev A, Rauschendorf M, Costanzo F, Calmels N, Obringer C, Sarasin A, et al.
Sci Rep . 2020 Jan; 10(1):1105. PMID: 31980658
Cockayne syndrome (CS) is a rare genetic disorder caused by mutations (dysfunction) in CSA and CSB. CS patients exhibit mild photosensitivity and severe neurological problems. Currently, CS diagnosis is based...
3.
Epanchintsev A, Costanzo F, Rauschendorf M, Caputo M, Ye T, Donnio L, et al.
Mol Cell . 2017 Dec; 68(6):1054-1066.e6. PMID: 29225035
Cockayne syndrome (CS) is caused by mutations in CSA and CSB. The CSA and CSB proteins have been linked to both promoting transcription-coupled repair and restoring transcription following DNA damage....
4.
Hofrichter M, Nimtz L, Tigges J, Kabiri Y, Schroter F, Royer-Pokora B, et al.
Stem Cell Res . 2017 Nov; 25:72-82. PMID: 29112887
Developmental neurotoxicity (DNT) testing performed in rats is resource-intensive (costs, time, animals) and bears the issue of species extrapolation. Thus, reliable alternative human-based approaches are needed for predicting neurodevelopmental toxicity....
5.
Donnio L, Bidon B, Hashimoto S, May M, Epanchintsev A, Ryan C, et al.
Hum Mol Genet . 2017 Apr; 26(11):2062-2075. PMID: 28369444
Mediator occupies a key role in protein coding genes expression in mediating the contacts between gene specific factors and the basal transcription machinery but little is known regarding the role...
6.
Epanchintsev A, Shyamsunder P, Verma R, Lyakhovich A
Mol Carcinog . 2014 Nov; 54(12):1686-99. PMID: 25358651
Fanconi anemia (FA) is a rare autosomal recessive genetic disorder associated with a bone-marrow failure, genome instability, hypersensitivity to DNA crosslinking agents and a predisposition to cancer. Mutations have been...
7.
Kristensen U, Epanchintsev A, Rauschendorf M, Laugel V, Stevnsner T, Bohr V, et al.
Proc Natl Acad Sci U S A . 2013 Jun; 110(25):E2261-70. PMID: 23733932
Cockayne syndrome type B ATPase (CSB) belongs to the SwItch/Sucrose nonfermentable family. Its mutations are linked to Cockayne syndrome phenotypes and classically are thought to be caused by defects in...
8.
Lodygin D, Tarasov V, Epanchintsev A, Berking C, Knyazeva T, Korner H, et al.
Cell Cycle . 2008 Aug; 7(16):2591-600. PMID: 18719384
Recently, we and others identified the microRNA miR-34a as a target of the tumor suppressor gene product p53. Ectopic miR-34a induces a G(1) cell cycle arrest, senescence and apoptosis. Here...
9.
Tarasov V, Jung P, Verdoodt B, Lodygin D, Epanchintsev A, Menssen A, et al.
Cell Cycle . 2007 Jun; 6(13):1586-93. PMID: 17554199
In a genome-wide screen for microRNAs regulated by the transcription factor encoded by the p53 tumor suppressor gene we found that after p53-activation the abundance of thirty-four miRNAs was significantly...
10.
Korner H, Epanchintsev A, Berking C, Schuler-Thurner B, Speicher M, Menssen A, et al.
Cell Cycle . 2007 Feb; 6(2):189-98. PMID: 17314512
Malignant melanoma is still poorly understood at the genomic level. Recently, a new technique for the high-resolution analysis of copy number changes named digital karyotyping was introduced. This approach is...