Alexey Bogush
Overview
Explore the profile of Alexey Bogush including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
313
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Recent Articles
1.
Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching
Dawicki-McKenna J, Felix A, Waxman E, Cheng C, Amado D, Ranum P, et al.
Nat Commun
. 2023 May;
14(1):2628.
PMID: 37149717
Alternative splicing of neuronal genes is controlled partly by the coordinated action of polypyrimidine tract binding proteins (PTBPs). While PTBP1 is ubiquitously expressed, PTBP2 is predominantly neuronal. Here, we define...
2.
Scarborough E, Uchida K, Vogel M, Erlitzki N, Iyer M, Phyo S, et al.
Nat Commun
. 2021 Mar;
12(1):1547.
PMID: 33707436
Hypertension, exercise, and pregnancy are common triggers of cardiac remodeling, which occurs primarily through the hypertrophy of individual cardiomyocytes. During hypertrophy, stress-induced signal transduction increases cardiomyocyte transcription and translation, which...
3.
Heffler J, Shah P, Robison P, Phyo S, Veliz K, Uchida K, et al.
Circ Res
. 2019 Dec;
126(3):e10-e26.
PMID: 31822208
Mechanical forces are transduced to nuclear responses via the linkers of the nucleoskeleton and cytoskeleton (LINC) complex, which couples the cytoskeleton to the nuclear lamina and associated chromatin. While disruption...
4.
Brautigam H, Moreno C, Steele J, Bogush A, Dickstein D, Kwok J, et al.
Sci Rep
. 2015 Nov;
5:17042.
PMID: 26608390
The presenilin 1 (PSEN1) L271V mutation causes early-onset familial Alzheimer's disease by disrupting the alternative splicing of the PSEN1 gene, producing some transcripts harboring the L271V point mutation and other...
5.
Tan W, Naniche N, Bogush A, Pedrini S, Trotti D, Pasinelli P
J Neurosci
. 2013 Jul;
33(28):11588-98.
PMID: 23843527
Mutations in superoxide dismutase 1 (SOD1) cause amyotrophic lateral sclerosis (ALS) in 20% of familial cases (fALS). Mitochondria are one of the targets of mutant SOD1 (mutSOD1) toxicity. We previously...
6.
Keilani S, Chandwani S, Dolios G, Bogush A, Beck H, Hatzopoulos A, et al.
J Neurosci
. 2012 May;
32(20):6808-18.
PMID: 22593050
DARPP-32 (dopamine and adenosine 3', 5'-cyclic monophosphate cAMP-regulated phosphoprotein, 32 kDa) is a striatal-enriched protein that mediates signaling by dopamine and other first messengers in the medium spiny neurons. The...
7.
Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, et al.
Glia
. 2011 Jul;
59(11):1719-31.
PMID: 21769946
Dysregulation of glutamate handling ensuing downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is implicated in excitotoxic degeneration of motor neurons in amyotrophic lateral sclerosis (ALS)....
8.
Page M, Bao L, Andre P, Pelta-Heller J, Sluzas E, Gonzalez-Alegre P, et al.
Neurobiol Dis
. 2010 May;
39(3):318-26.
PMID: 20460154
Early onset torsion dystonia is an autosomal dominant movement disorder of variable penetrance caused by a glutamic acid, i.e. DeltaE, deletion in DYT1, encoding the protein TorsinA. Genetic and structural...
9.
Boston-Howes W, Williams E, Bogush A, Scolere M, Pasinelli P, Trotti D
Exp Neurol
. 2008 Jul;
213(1):229-37.
PMID: 18625223
Synaptic accumulation of glutamate causes neuronal death in many neurodegenerative pathologies including amyotrophic lateral sclerosis. Drugs capable of increasing glutamate uptake could therefore be therapeutically effective. We screened in a...
10.
Pedrini S, Bogush A, Ehrlich M
J Neurochem
. 2008 May;
106(2):917-24.
PMID: 18485106
Mature striatal medium size spiny neurons express the dopamine and cAMP-regulated phosphoprotein, 32 kDa (DARPP-32), but little is known about the mechanisms regulating its levels, or the specification of fully...