Alexei Degterev
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Explore the profile of Alexei Degterev including associated specialties, affiliations and a list of published articles.
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87
Citations
8823
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Recent Articles
1.
Jetton D, Muendlein H, Connolly W, Magri Z, Smirnova I, Batorsky R, et al.
Cell Rep
. 2024 Aug;
43(8):114641.
PMID: 39154339
Caspase-8-dependent pyroptosis has been shown to mediate host protection from Yersinia infection. For this mode of cell death, the kinase activity of receptor-interacting protein kinase 1 (RIPK1) is required, but...
2.
Gautam A, Boyd D, Nikhar S, Zhang T, Siokas I, Van de Velde L, et al.
Nature
. 2024 Apr;
628(8009):835-843.
PMID: 38600381
Severe influenza A virus (IAV) infections can result in hyper-inflammation, lung injury and acute respiratory distress syndrome (ARDS), for which there are no effective pharmacological therapies. Necroptosis is an attractive...
3.
Vitale I, Pietrocola F, Guilbaud E, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ
. 2023 Apr;
30(5):1097-1154.
PMID: 37100955
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have...
4.
Johnson J, Yaron T, Huntsman E, Kerelsky A, Song J, Regev A, et al.
Nature
. 2023 Jan;
613(7945):759-766.
PMID: 36631611
Protein phosphorylation is one of the most widespread post-translational modifications in biology. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and...
5.
Maslov L, Popov S, Naryzhnaya N, Mukhomedzyanov A, Kurbatov B, Derkachev I, et al.
Apoptosis
. 2022 Aug;
27(9-10):697-719.
PMID: 35986803
In the last 10 years, mortality from acute myocardial infarction (AMI) has not significantly decreased. This situation is associated with the absence in clinical practice of highly effective drugs capable...
6.
Muendlein H, Connolly W, Magri Z, Jetton D, Smirnova I, Degterev A, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(24):e2113872119.
PMID: 35666872
ZBP1 is widely recognized as a mediator of cell death for its role in initiating necroptotic, apoptotic, and pyroptotic cell death pathways in response to diverse pathogenic infection. Herein, we...
7.
Wu L, Chung J, Cao T, Jin G, Edmiston 3rd W, Hickman S, et al.
Cell Death Dis
. 2021 Nov;
12(11):1064.
PMID: 34753914
Traumatic brain injury (TBI) is a leading cause of death and disability with no specific effective therapy, in part because disease driving mechanisms remain to be elucidated. Receptor interacting protein...
8.
Delanghe T, Huyghe J, Lee S, Priem D, Van Coillie S, Gilbert B, et al.
Cell Death Dis
. 2021 Jul;
12(7):699.
PMID: 34262020
Butylate hydroxyanisole (BHA) is a synthetic phenol that is widely utilized as a preservative by the food and cosmetic industries. The antioxidant properties of BHA are also frequently used by...
9.
Siokas I, Zhang D, Poltorak A, Muendlein H, Degterev A
Curr Protoc
. 2021 Jun;
1(6):e156.
PMID: 34106523
A large protein complex, containing RIPK1, RIPK3, and caspase-8 and known as Complex II, has emerged as one of the key mediators of cell death downstream from a range of...
10.
Zelic M, Pontarelli F, Woodworth L, Zhu C, Mahan A, Ren Y, et al.
Cell Rep
. 2021 May;
35(6):109112.
PMID: 33979622
Receptor interacting protein kinase 1 (RIPK1) mediates cell death and inflammatory signaling and is increased in multiple sclerosis (MS) brain samples. Here, we investigate the role of glial RIPK1 kinase...