Alexandra L Ghaben
Overview
Explore the profile of Alexandra L Ghaben including associated specialties, affiliations and a list of published articles.
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12
Citations
1199
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Recent Articles
1.
Crewe C, Funcke J, Li S, Joffin N, Gliniak C, Ghaben A, et al.
Cell Metab
. 2021 Aug;
33(9):1853-1868.e11.
PMID: 34418352
Adipocytes undergo intense energetic stress in obesity resulting in loss of mitochondrial mass and function. We have found that adipocytes respond to mitochondrial stress by rapidly and robustly releasing small...
2.
Zhang Z, Funcke J, Zi Z, Zhao S, Straub L, Zhu Y, et al.
Cell Metab
. 2021 Jun;
33(8):1624-1639.e9.
PMID: 34174197
Iron overload is positively associated with diabetes risk. However, the role of iron in adipose tissue remains incompletely understood. Here, we report that transferrin-receptor-1-mediated iron uptake is differentially required for...
3.
Kusminski C, Ghaben A, Morley T, Samms R, Adams A, An Y, et al.
Diabetes
. 2019 Dec;
69(3):313-330.
PMID: 31882562
Obesity-associated type 2 diabetes mellitus (T2DM) entails insulin resistance and loss of β-cell mass. Adipose tissue mitochondrial dysfunction is emerging as a key component in the etiology of T2DM. Identifying...
4.
Zhang Z, Shao M, Hepler C, Zi Z, Zhao S, An Y, et al.
J Clin Invest
. 2019 Sep;
129(12):5327-5342.
PMID: 31503545
Dermal adipose tissue (also known as dermal white adipose tissue and herein referred to as dWAT) has been the focus of much discussion in recent years. However, dWAT remains poorly...
5.
Crewe C, Zhu Y, Paschoal V, Joffin N, Ghaben A, Gordillo R, et al.
JCI Insight
. 2019 Jul;
5.
PMID: 31310592
The synthesis of lipid and sterol species through de novo lipogenesis (DNL) is regulated by two functionally overlapping but distinct transcription factors: the sterol regulatory element-binding proteins (SREBPs) and carbohydrate...
6.
Bu D, Crewe C, Kusminski C, Gordillo R, Ghaben A, Kim M, et al.
JCI Insight
. 2019 Mar;
5.
PMID: 30896449
We have previously reported that the carboxy-terminal proteolytic cleavage product of the COL6α3 chain that we refer to as "endotrophin" has potent effects on transformed mammary ductal epithelial cells in...
7.
Ghaben A, Scherer P
Nat Rev Mol Cell Biol
. 2019 Jan;
20(4):242-258.
PMID: 30610207
Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major...
8.
Hepler C, Shan B, Zhang Q, Henry G, Shao M, Vishvanath L, et al.
Elife
. 2018 Sep;
7.
PMID: 30265241
Editorial Note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is...
9.
Xia J, Sun K, Hepler C, Ghaben A, Gupta R, An Y, et al.
Diabetologia
. 2017 Dec;
61(4):932-941.
PMID: 29224189
Aim/hypothesis: Adiponectin (APN), a circulating hormone secreted by mature adipocytes, has been extensively studied because it has beneficial metabolic effects. While many studies have focused on the congenital loss of...
10.
Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben A, Shao M, et al.
Diabetes
. 2017 Sep;
66(11):2789-2799.
PMID: 28877911
Transcripts of key enzymes in the Leloir pathway of galactose metabolism in mouse livers are significantly increased after chronic high-fat/high-sucrose feeding. UDP-galactose-4-epimerase (GALE) is the last enzyme in this pathway...