Alexandra A Kuznetsova
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Explore the profile of Alexandra A Kuznetsova including associated specialties, affiliations and a list of published articles.
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23
Citations
219
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Recent Articles
1.
Vasilyeva S, Kuznetsova A, Baranovskaya E, Kuznetsov N, Lomzov A, Pyshnyi D
Bioorg Chem
. 2022 Jul;
127:105987.
PMID: 35777231
Efficient protocols were developed for the synthesis of a new compounds - nucleoside 5'-α-iminophosphates using the Staudinger reaction. These substances are alpha-phosphate mimetic nucleotide in which an oxygen atom is...
2.
Davletgildeeva A, Kuznetsova A, Novopashina D, Ishchenko A, Saparbaev M, Fedorova O, et al.
Int J Mol Sci
. 2022 Mar;
23(5).
PMID: 35270011
Apurinic/apyrimidinic (AP)-endonucleases are multifunctional enzymes that are required for cell viability. AP-endonucleases incise DNA 5' to an AP-site; can recognize and process some damaged nucleosides; and possess 3'-phosphodiesterase, 3'-phosphatase, and...
3.
Zakharova M, Kuznetsova A, Uvarova V, Fomina A, Kozlovskaya L, Kaliberda E, et al.
Front Pharmacol
. 2021 Dec;
12:773198.
PMID: 34938188
The design of effective target-specific drugs for COVID-19 treatment has become an intriguing challenge for modern science. The SARS-CoV-2 main protease, M, responsible for the processing of SARS-CoV-2 polyproteins and...
4.
Kuznetsova A, Senchurova S, Ishchenko A, Saparbaev M, Fedorova O, Kuznetsov N
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445579
Apurinic/apyrimidinic (AP) endonucleases Nfo () and APE1 (human) represent two conserved structural families of enzymes that cleave AP-site-containing DNA in base excision repair. Nfo and APE1 have completely different structures...
5.
Kuznetsova A, Fedorova O, Kuznetsov N
Front Cell Dev Biol
. 2020 Dec;
8:595687.
PMID: 33330484
Human telomeres as well as more than 40% of human genes near the promoter regions have been found to contain the sequence that may form a G-quadruplex structure. Other non-canonical...
6.
Davletgildeeva A, Kuznetsova A, Fedorova O, Kuznetsov N
Front Cell Dev Biol
. 2020 Nov;
8:590848.
PMID: 33195255
The primary role of apurinic/apyrimidinic (AP) endonuclease APE1 in human cells is the cleavage of the sugar phosphate backbone 5' to an AP site in DNA to produce a single-strand...
7.
Bulygin A, Kuznetsova A, Vorobjev Y, Fedorova O, Kuznetsov N
Molecules
. 2020 Sep;
25(17).
PMID: 32872297
Human apurinic/apyrimidinic (AP) endonuclease APE1 hydrolyzes phosphodiester bonds on the 5' side of an AP-site, and some damaged nucleotides such as 1,N6-ethenoadenosine (εA), α-adenosine (αA), and 5,6-dihydrouridine (DHU). To investigate...
8.
Tyugashev T, Vorobjev Y, Kuznetsova A, Lukina M, Kuznetsov N, Fedorova O
J Phys Chem B
. 2019 May;
123(23):4878-4887.
PMID: 31117610
Human 8-oxoguanine-DNA glycosylase (hOGG1) possesses very high specificity for 8-oxoguanine (oxoG), even though this damaged base differs from normal guanine by only two atoms. Our aim was to determine the...
9.
Kuznetsova A, Matveeva A, Milov A, Vorobjev Y, Dzuba S, Fedorova O, et al.
Nucleic Acids Res
. 2018 Oct;
46(21):11454-11465.
PMID: 30329131
Human apurinic/apyrimidinic (AP) endonuclease APE1 catalyses the hydrolysis of phosphodiester bonds on the 5' side of an AP-site (in the base excision repair pathway) and of some damaged nucleotides (in...
10.
Kuznetsova A, Fedorova O, Kuznetsov N
Molecules
. 2018 Aug;
23(9).
PMID: 30134601
Human apurinic/apyrimidinic (AP)-endonuclease APE1 is one of the key enzymes taking part in the repair of damage to DNA. The primary role of APE1 is the initiation of the repair...