Alexander Wirth
Overview
Explore the profile of Alexander Wirth including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
400
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Recent Articles
1.
Bijata M, Wirth A, Wlodarczyk J, Ponimaskin E
J Cell Sci
. 2024 Sep;
137(19).
PMID: 39279505
Serotonin regulates multiple physiological and pathological processes in the brain, including mood and cognition. The serotonin receptors 5-HT1AR (also known as HTR1A) and 5-HT7R (also known as HTR7) have emerged...
2.
Wirth A, Ponimaskin E
Front Physiol
. 2023 Jan;
13:1088840.
PMID: 36699687
The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner participating in...
3.
Wirth A, Labus J, Abdel Galil D, Schill Y, Schmidt S, Bunke T, et al.
J Biol Chem
. 2022 May;
298(6):102048.
PMID: 35597282
The small GTPase Cdc42 exists in the form of two alternatively spliced variants that are modified by hydrophobic chains: the ubiquitously expressed Cdc42-prenyl and a brain-specific isoform that can be...
4.
Catanese A, Rajkumar S, Sommer D, Freisem D, Wirth A, Aly A, et al.
EMBO Mol Med
. 2021 Jun;
13(7):e13131.
PMID: 34125498
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still missing effective therapeutic strategies. Although manipulation of neuronal excitability has been tested in murine and human ALS models,...
5.
Rabanal-Ruiz Y, Byron A, Wirth A, Madsen R, Sedlackova L, Hewitt G, et al.
J Cell Biol
. 2021 Feb;
220(5).
PMID: 33635313
The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogenic and stress signals to control growth and metabolism. Activation of mTORC1 by amino acids and growth factors involves recruitment of...
6.
Wirth A, Wolf B, Huang C, Glage S, Hofer S, Bankstahl M, et al.
Geroscience
. 2021 Jan;
43(2):673-690.
PMID: 33517527
Ageing provokes a plethora of molecular, cellular and physiological deteriorations, including heart failure, neurodegeneration, metabolic maladaptation, telomere attrition and hair loss. Interestingly, on the molecular level, the capacity to induce...
7.
Gorinski N, Wojciechowski D, Guseva D, Abdel Galil D, Mueller F, Wirth A, et al.
J Biol Chem
. 2020 Mar;
295(18):5970-5983.
PMID: 32184353
Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with...
8.
Maglione M, Kochlamazashvili G, Eisenberg T, Racz B, Michael E, Toppe D, et al.
Sci Rep
. 2019 Dec;
9(1):19616.
PMID: 31873156
Aging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a...
9.
Gorinski N, Bijata M, Prasad S, Wirth A, Abdel Galil D, Zeug A, et al.
Nat Commun
. 2019 Sep;
10(1):3924.
PMID: 31477731
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and...
10.
Wirth A, Holst K, Ponimaskin E
Prog Neurobiol
. 2016 Mar;
151:35-56.
PMID: 27013076
Serotonin (5-hydroxytrympamine or 5-HT) is one of the phylogenetically oldest neurotransmitters, and the serotonergic system is among the earliest developed neuronal systems. Serotonin is critically involved in regulating multiple physiological...