Alexander V Grishaev
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Explore the profile of Alexander V Grishaev including associated specialties, affiliations and a list of published articles.
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7
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11
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Recent Articles
1.
Liu Y, Hatch H, Yuan G, Shen V, Grishaev A, Panchal J, et al.
J Phys Chem Lett
. 2024 Dec;
15(50):12401-12407.
PMID: 39656919
Nonspecific protein-protein interactions (PPIs) are key to understanding the behavior of proteins in solutions. However, experimentally measuring anisotropic PPIs as a function of orientation and distance has been challenging. Here,...
2.
Hatch H, Bergonzo C, Blanco M, Yuan G, Grudinin S, Lund M, et al.
J Chem Phys
. 2024 Sep;
161(9).
PMID: 39234967
We develop a multiscale coarse-grain model of the NIST Monoclonal Antibody Reference Material 8671 (NISTmAb) to enable systematic computational investigations of high-concentration physical instabilities such as phase separation, clustering, and...
3.
Yuan G, Salipante P, Hudson S, Gillilan R, Huang Q, Hatch H, et al.
Mol Pharm
. 2024 Aug;
21(9):4553-4564.
PMID: 39163212
The solution viscosity and protein-protein interactions (PPIs) as a function of temperature (4-40 °C) were measured at a series of protein concentrations for a monoclonal antibody (mAb) with different formulation...
4.
Thelen J, Leite W, Urban V, ONeill H, Grishaev A, Curtis J, et al.
ACS Nano
. 2024 Jan;
18(2):1464-1476.
PMID: 38175970
The mRNA technology has emerged as a rapid modality to develop vaccines during pandemic situations with the potential to protect against endemic diseases. The success of mRNA in producing an...
5.
Chen J, Borkiewicz O, Grishaev A, Zhang F, Bera M, Ruett U, et al.
Chemistry
. 2023 Jan;
29(31):e202203551.
PMID: 36646645
We communicate a feasibility study for high-resolution structural characterization of biomacromolecules in aqueous solution from X-ray scattering experiments measured over a range of scattering vectors (q) that is approximately two...
6.
HIV-1 gp120-CD4-Induced Antibody Complex Elicits CD4 Binding Site-Specific Antibody Response in Mice
Galkin A, Chen Y, Guenaga J, ODell S, Acevedo R, Steinhardt J, et al.
J Immunol
. 2020 Feb;
204(6):1543-1561.
PMID: 32066595
Elicitation of broadly neutralizing Ab (bNAb) responses toward the conserved HIV-1 envelope (Env) CD4 binding site (CD4bs) by vaccination is an important goal for vaccine development and yet to be...
7.
Grishaev A
Adv Exp Med Biol
. 2017 Dec;
1009:215-227.
PMID: 29218562
Biomolecular applications of solution X-ray and neutron scattering (SAXS and SANS, respectively) started in late 1960s - early 1970s but were relatively limited in their ability to provide a detailed...