Alexander Schonhuth
Overview
Explore the profile of Alexander Schonhuth including associated specialties, affiliations and a list of published articles.
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Articles
48
Citations
1429
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Recent Articles
1.
Balvert M, Cooper-Knock J, Stamp J, Byrne R, Mourragui S, van Gils J, et al.
Genome Biol
. 2025 Jan;
26(1):12.
PMID: 39833965
No abstract available.
2.
Balvert M, Cooper-Knock J, Stamp J, Byrne R, Mourragui S, van Gils J, et al.
Genome Biol
. 2024 Nov;
25(1):296.
PMID: 39563431
Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other...
3.
Kang X, Zhang W, Li Y, Luo X, Schonhuth A
Nat Commun
. 2024 Oct;
15(1):8665.
PMID: 39375348
Different strains of identical species can vary substantially in terms of their spectrum of biomedically relevant phenotypes. Reconstructing the genomes of microbial communities at the level of their strains poses...
4.
Tas G, Westerdijk T, Postma E, Veldink J, Schonhuth A, Balvert M
Bioinformatics
. 2024 May;
40(6).
PMID: 38775680
Motivation: The completion of the genome has paved the way for genome-wide association studies (GWAS), which explained certain proportions of heritability. GWAS are not optimally suited to detect non-linear effects...
5.
Kang X, Xu J, Luo X, Schonhuth A
Genome Biol
. 2023 Dec;
24(1):275.
PMID: 38041098
Although generally superior, hybrid approaches for correcting errors in third-generation sequencing (TGS) reads, using next-generation sequencing (NGS) reads, mistake haplotype-specific variants for errors in polyploid and mixed samples. We suggest...
6.
Ray S, Lall S, Mukhopadhyay A, Bandyopadhyay S, Schonhuth A
Artif Intell Med
. 2022 Dec;
134:102418.
PMID: 36462892
The COVID-19 pandemic has been keeping asking urgent questions with respect to therapeutic options. Existing drugs that can be repurposed promise rapid implementation in practice because of their prior approval....
7.
Luo X, Kang X, Schonhuth A
Nat Commun
. 2022 Nov;
13(1):6657.
PMID: 36333324
Error correction is the canonical first step in long-read sequencing data analysis. Current self-correction methods, however, are affected by consensus sequence induced biases that mask true variants in haplotypes of...
8.
Kang X, Luo X, Schonhuth A
Nucleic Acids Res
. 2022 Jul;
50(17):e101.
PMID: 35776122
Next-generation sequencing-based metagenomics has enabled to identify microorganisms in characteristic habitats without the need for lengthy cultivation. Importantly, clinically relevant phenomena such as resistance to medication, virulence or interactions with...
9.
Luo X, Kang X, Schonhuth A
Front Genet
. 2022 Jun;
13:868280.
PMID: 35646097
Microbial communities are usually highly diverse and often involve multiple strains from the participating species due to the rapid evolution of microorganisms. In such a complex microecosystem, different strains may...
10.
Luo X, Kang X, Schonhuth A
Genome Biol
. 2022 Jan;
23(1):29.
PMID: 35057847
Haplotype-resolved de novo assembly of highly diverse virus genomes is critical in prevention, control and treatment of viral diseases. Current methods either can handle only relatively accurate short read data,...