Alexander Scherl
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Explore the profile of Alexander Scherl including associated specialties, affiliations and a list of published articles.
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49
Citations
1083
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Recent Articles
31.
Francois P, Scherl A, Hochstrasser D, Schrenzel J
J Proteomics
. 2009 Nov;
73(4):701-8.
PMID: 19879388
Staphylococcus aureus is an important human and veterinary pathogen that causes a wide variety of infections ranging from benign skin infections to life threatening diseases. Recently, important changes in the...
32.
Tsai Y, Scherl A, Shaw J, Mackay C, Shaffer S, Langridge-Smith P, et al.
J Am Soc Mass Spectrom
. 2009 Sep;
20(11):2154-66.
PMID: 19773183
We present a precursor ion independent top-down algorithm (PIITA) for use in automated assignment of protein identifications from tandem mass spectra of whole proteins. To acquire the data, we utilize...
33.
Panchaud A, Scherl A, Shaffer S, von Haller P, Kulasekara H, Miller S, et al.
Anal Chem
. 2009 Jul;
81(15):6481-8.
PMID: 19572557
Data-dependent precursor ion selection is widely used in shotgun proteomics to profile the protein components of complex samples. Although very popular, this bottom-up method presents major drawbacks in terms of...
34.
Singh P, Shaffer S, Scherl A, Holman C, Pfuetzner R, Larson Freeman T, et al.
Anal Chem
. 2008 Oct;
80(22):8799-806.
PMID: 18947195
Protein-protein interactions are key to function and regulation of many biological pathways. To facilitate characterization of protein-protein interactions using mass spectrometry, a new data acquisition/analysis pipeline was designed. The goal...
35.
Scherl A, Tsai Y, Shaffer S, Goodlett D
Proteomics
. 2008 Jul;
8(14):2791-7.
PMID: 18655048
Although mass spectrometers are capable of providing high mass accuracy data, assignment of true monoisotopic precursor ion mass is complicated during data-dependent ion selection for LC-MS/MS analysis of complex mixtures....
36.
Scherl A, Shaffer S, Taylor G, Hernandez P, Appel R, Binz P, et al.
J Am Soc Mass Spectrom
. 2008 Apr;
19(6):891-901.
PMID: 18417358
The advantages and disadvantages of acquiring tandem mass spectra by collision-induced dissociation (CID) of peptides in linear ion trap Fourier-transform hybrid instruments are described. These instruments offer the possibility to...
37.
Scherl A, Shaffer S, Taylor G, Kulasekara H, Miller S, Goodlett D
Anal Chem
. 2008 Jan;
80(4):1182-91.
PMID: 18211032
Gas-phase fractionation (GPF) is an efficient and straightforward method to increase proteome coverage. In this report, optimal m/z ranges were calculated based on genomic complexity and experimental data. Then, theoretical...
38.
Francois P, Scherl A, Hochstrasser D, Schrenzel J
Methods Mol Biol
. 2007 Nov;
391:179-99.
PMID: 18025678
Over the past decade numerous genomes of pathogenic bacteria were fully sequenced and annotated, while others are continuously being sequenced and published. To date, the sequences of >440 bacterial genomes...
39.
Scherl A, Francois P, Charbonnier Y, Deshusses J, Koessler T, Huyghe A, et al.
BMC Genomics
. 2006 Nov;
7:296.
PMID: 17121677
Background: To unravel molecular targets involved in glycopeptide resistance, three isogenic strains of Staphylococcus aureus with different susceptibility levels to vancomycin or teicoplanin were subjected to whole-genome microarray-based transcription and...
40.
Nunn B, Shaffer S, Scherl A, Gallis B, Wu M, Miller S, et al.
Brief Funct Genomic Proteomic
. 2006 Jun;
5(2):154-68.
PMID: 16798750
Shotgun proteomics is rapidly becoming one of the most efficient and popular tools to examine protein expression in cells. Numerous laboratories now have a wide array of low- and high-performance...