Alexander Scherl
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Explore the profile of Alexander Scherl including associated specialties, affiliations and a list of published articles.
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49
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1083
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Recent Articles
11.
Francois P, Scherl A, Hochstrasser D, Schrenzel J
Methods Mol Biol
. 2013 Oct;
1085:231-50.
PMID: 24085700
Over the last two decades, numerous genomes of pathogenic bacteria have been fully sequenced and annotated, while others are continuously being sequenced. To date, the sequences of more than 8,500...
12.
Apcher S, Millot G, Daskalogianni C, Scherl A, Manoury B, Fahraeus R
Proc Natl Acad Sci U S A
. 2013 Oct;
110(44):17951-6.
PMID: 24082107
The scanning of maturing mRNAs by ribosomes plays a key role in the mRNA quality control process. When ribosomes first engage with the newly synthesized mRNA, and if peptides are...
13.
Pak H, Nikitin F, Gluck F, Lisacek F, Scherl A, Muller M
J Am Soc Mass Spectrom
. 2013 Sep;
24(12):1862-71.
PMID: 24006250
Data-independent mass spectrometry activates all ion species isolated within a given mass-to-charge window (m/z) regardless of their abundance. This acquisition strategy overcomes the traditional data-dependent ion selection boosting data reproducibility...
14.
Sajic T, Hainard A, Scherl A, Wohlwend A, Negro F, Sanchez J, et al.
Sci Rep
. 2013 Aug;
3:2350.
PMID: 23917405
STAT6 interacts with PPARγ to elicit macrophage polarization towards an anti-inflammatory, insulin-sensitizing phenotype. Mice deficient in STAT6 display liver lipid accumulation (hepatosteatosis). Rosiglitazone (RSG), a PPARγ agonist, ameliorates hepatosteatosis and...
15.
Acosta-Martin A, Coelho Graca D, Antinori P, Clerici L, Hartmer R, Meyer M, et al.
Anal Chem
. 2013 Jul;
85(16):7971-5.
PMID: 23883289
Precise and accurate quantification of proteins is essential in clinical laboratories. Here, we present a mass spectrometry (MS)-based method for the quantification of intact proteins in an ion trap mass...
16.
Gray T, Murray E, Nowicki M, Remnant L, Scherl A, Muller P, et al.
Protein Sci
. 2013 Jun;
22(9):1266-78.
PMID: 23780840
Many regulatory proteins are homo-oligomeric and designing assays that measure self-assembly will provide novel approaches to study protein allostery and screen for novel small molecule modulators of protein interactions. We...
17.
Bouchal P, Dvorakova M, Scherl A, Garbis S, Nenutil R, Vojtesek B
Proteomics
. 2013 Jan;
13(7):1053-8.
PMID: 23303686
Proteomics profiling of intact proteins based on MALDI-TOF MS and derived platforms has been used in cancer biomarker discovery studies. This approach suffers from a number of limitations such as...
18.
Gluck F, Hoogland C, Antinori P, Robin X, Nikitin F, Zufferey A, et al.
J Proteomics
. 2013 Jan;
79:146-60.
PMID: 23277275
High throughput protein identification and quantification analysis based on mass spectrometry are fundamental steps in most proteomics projects. Here, we present EasyProt (available at http://easyprot.unige.ch), a new platform for mass...
19.
Lehmann S, Hoofnagle A, Hochstrasser D, Brede C, Glueckmann M, Cocho J, et al.
Clin Chem Lab Med
. 2012 Nov;
51(5):919-35.
PMID: 23183755
Proteomics studies typically aim to exhaustively detect peptides/proteins in a given biological sample. Over the past decade, the number of publications using proteomics methodologies has exploded. This was made possible...
20.
Coelho Graca D, Lescuyer P, Clerici L, Tsybin Y, Hartmer R, Meyer M, et al.
J Am Soc Mass Spectrom
. 2012 Aug;
23(10):1750-6.
PMID: 22869297
A mass spectrometry-based assay combining the specificity of selected reaction monitoring and the protein ion activation capabilities of electron transfer dissociation was developed and employed for the rapid identification of...