Alexander S Spirin
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Explore the profile of Alexander S Spirin including associated specialties, affiliations and a list of published articles.
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26
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525
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Recent Articles
1.
Sogorin E, Agalarov S, Spirin A
Sci Rep
. 2016 Apr;
6:24518.
PMID: 27075299
The recording of the luciferase-generated luminescence in the eukaryotic cell-free translation system programmed with mRNA encoding firefly luciferase (Luc-mRNA) showed that the addition of free exogenous mRNAs into the translation...
2.
Afonina Z, Myasnikov A, Shirokov V, Klaholz B, Spirin A
Nucleic Acids Res
. 2014 Dec;
43(1):618-28.
PMID: 25520190
Using sedimentation and cryo electron tomography techniques, the conformations of eukaryotic polyribosomes formed in a long-term cell-free translation system were analyzed over all the active system lifetime (20-30 translation rounds...
3.
Myasnikov A, Afonina Z, Menetret J, Shirokov V, Spirin A, Klaholz B
Nat Commun
. 2014 Nov;
5:5294.
PMID: 25376914
During protein synthesis, several ribosomes bind to a single messenger RNA (mRNA) forming large macromolecular assemblies called polyribosomes. Here we report the detailed molecular structure of a 100 MDa eukaryotic...
4.
Afonina Z, Myasnikov A, Shirokov V, Klaholz B, Spirin A
Nucleic Acids Res
. 2014 Jul;
42(14):9461-9.
PMID: 25016525
The polyribosomes newly formed on recombinant GFP-encoding mRNAs in a wheat germ cell-free translation system were analyzed using cryo-electron tomography, with sub-tomogram averaging of polysomal ribosomes and reconstruction of 3D...
5.
Agalarov S, Sakharov P, Fattakhova D, Sogorin E, Spirin A
Sci Rep
. 2014 Mar;
4:4438.
PMID: 24657959
The recombinant mRNAs with 5'-untranslated region, called omega leader, of tobacco mosaic virus RNA are known to be well translated in eukaryotic cell-free systems, even if deprived of cap structure....
6.
Vassilenko K, Alekhina O, Dmitriev S, Shatsky I, Spirin A
Nucleic Acids Res
. 2011 Mar;
39(13):5555-67.
PMID: 21415006
According to the model of translation initiation in eukaryotes, the 40S ribosomal subunit binds to capped 5'-end of mRNA and subsequently migrates along 5'-UTR in searching for initiation codon. However,...
7.
Agalarov S, Sogorin E, Shirokikh N, Spirin A
Biochem Biophys Res Commun
. 2010 Dec;
404(1):250-3.
PMID: 21114960
The 5'-untranslated sequence of tobacco mosaic virus RNA--the so called omega leader--is a well-known translational enhancer. The structure of the omega RNA has unusual features. Despite the absence of extensive...
8.
Shirokikh N, Alkalaeva E, Vassilenko K, Afonina Z, Alekhina O, Kisselev L, et al.
Nucleic Acids Res
. 2009 Nov;
38(3):e15.
PMID: 19910372
Inhibition of primer extension by ribosome-mRNA complexes (toeprinting) is a proven and powerful technique for studying mechanisms of mRNA translation. Here we have assayed an advanced toeprinting approach that employs...
9.
Efimov A, Spirin A
Biochem Biophys Res Commun
. 2009 Aug;
388(1):127-30.
PMID: 19646956
The regular (CAA)(n) polyribonucleotide, as well as the omega leader sequence containing (CAA)-rich core, have recently been shown to form cooperatively melted and compact structures. In this report, we propose...
10.