Alexander S Leonard
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Explore the profile of Alexander S Leonard including associated specialties, affiliations and a list of published articles.
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14
Citations
122
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Recent Articles
1.
Milia S, Leonard A, Leonard A, Mapel X, Bernal Ulloa S, Drogemuller C, et al.
Genome Res
. 2024 Dec;
PMID: 39694857
Cattle have been selectively bred for coat color, spotting, and depigmentation patterns. The assumed autosomal dominant inherited genetic variants underlying the characteristic white head of Fleckvieh, Simmental, and Hereford cattle...
2.
Genome assembly of wisent (Bison bonasus) uncovers a deletion that likely inactivates the THRSP gene
Bortoluzzi C, Mapel X, Neuenschwander S, Janett F, Pausch H, Leonard A
Commun Biol
. 2024 Nov;
7(1):1580.
PMID: 39604663
The wisent (Bison bonasus) is Europe's largest land mammal. We produced a HiFi read-based wisent assembly with a contig N50 value of 91 Mb containing 99.7% of the highly conserved...
3.
Leonard A, Mapel X, Pausch H
BMC Genomics
. 2024 Aug;
25(1):750.
PMID: 39090567
Background: Association testing between molecular phenotypes and genomic variants can help to understand how genotype affects phenotype. RNA sequencing provides access to molecular phenotypes such as gene expression and alternative...
4.
Lyu Y, Wang F, Cheng H, Han J, Dang R, Xia X, et al.
Sci Bull (Beijing)
. 2024 Jun;
69(21):3415-3424.
PMID: 38945748
During the past 3000 years, cattle on the Qinghai-Xizang Plateau have developed adaptive phenotypes under the selective pressure of hypoxia, ultraviolet (UV) radiation, and extreme cold. The genetic mechanism underlying...
5.
Mapel X, Kadri N, Leonard A, He Q, Lloret-Villas A, Bhati M, et al.
Nat Commun
. 2024 Feb;
15(1):1506.
PMID: 38374319
No abstract available.
6.
Leonard A, Mapel X, Pausch H
Genome Res
. 2024 Feb;
34(2):300-309.
PMID: 38355307
Expression and splicing quantitative trait loci (e/sQTL) are large contributors to phenotypic variability. Achieving sufficient statistical power for e/sQTL mapping requires large cohorts with both genotypes and molecular phenotypes, and...
7.
Mapel X, Kadri N, Leonard A, He Q, Lloret-Villas A, Bhati M, et al.
Nat Commun
. 2024 Jan;
15(1):674.
PMID: 38253538
Breeding bulls are well suited to investigate inherited variation in male fertility because they are genotyped and their reproductive success is monitored through semen analyses and thousands of artificial inseminations....
8.
Noskova A, Li C, Wang X, Leonard A, Pausch H, Kadri N
Nucleic Acids Res
. 2023 Nov;
51(22):12069-12075.
PMID: 37953306
The branch point sequence is a degenerate intronic heptamer required for the assembly of the spliceosome during pre-mRNA splicing. Disruption of this motif may promote alternative splicing and eventually cause...
9.
Xia X, Zhang F, Li S, Luo X, Peng L, Dong Z, et al.
Genome Biol
. 2023 Sep;
24(1):211.
PMID: 37723525
Background: Structural variations (SVs) in individual genomes are major determinants of complex traits, including adaptability to environmental variables. The Mongolian and Hainan cattle breeds in East Asia are of taurine...
10.
Leonard A, Crysnanto D, Mapel X, Bhati M, Pausch H
Genome Biol
. 2023 May;
24(1):124.
PMID: 37217946
Background: Several models and algorithms have been proposed to build pangenomes from multiple input assemblies, but their impact on variant representation, and consequently downstream analyses, is largely unknown. Results: We...