Alexander R Mackie
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Explore the profile of Alexander R Mackie including associated specialties, affiliations and a list of published articles.
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18
Citations
693
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Recent Articles
1.
Ledford D, Carr W, Moore W, Lugogo N, Mohan A, Chipps B, et al.
J Asthma Allergy
. 2024 Oct;
17:977-982.
PMID: 39398317
Purpose: Younger age of asthma onset (AAO) has been associated with an allergic phenotype, whereas eosinophilic phenotypes have been associated with older AAO. In randomized trials, biologic efficacy among adults...
2.
Gupta R, Mackie A, Misener S, Liu L, Losordo D, Kishore R
Lab Invest
. 2018 Feb;
98(5):682-691.
PMID: 29453401
Sonic Hedgehog (Shh) signaling induces neovascularization and angiogenesis. It is not known whether the hedgehog signaling pathway in endothelial cells is essential to angiogenesis. Smoothened (Smo) transduces hedgehog signaling across...
3.
Rai R, Ghosh A, Eren M, Mackie A, Levine D, Kim S, et al.
Cell Rep
. 2017 Nov;
21(6):1471-1480.
PMID: 29117554
Aging drives the occurrence of numerous diseases, including cardiovascular disease (CVD). Recent studies indicate that blood from young mice reduces age-associated pathologies. However, the "anti-aging" factors in juvenile circulation remain...
4.
Joladarashi D, Garikipati V, Thandavarayan R, Verma S, Mackie A, Khan M, et al.
J Am Coll Cardiol
. 2015 Nov;
66(20):2214-2226.
PMID: 26564600
Background: MicroRNA (miR) dysregulation in the myocardium has been implicated in cardiac remodeling after injury or stress. Objectives: The aim of this study was to explore the role of miR...
5.
Garikipati V, Krishnamurthy P, Verma S, Khan M, Abramova T, Mackie A, et al.
Stem Cells
. 2015 Aug;
33(12):3519-29.
PMID: 26235810
Poor survival and function of transplanted cells in ischemic and inflamed myocardium likely compromises the functional benefit of stem cell-based therapies. We have earlier reported that co-administration of interleukin (IL)-10...
6.
Thandavarayan R, Garikipati V, Joladarashi D, Babu S, Jeyabal P, Verma S, et al.
Exp Dermatol
. 2015 May;
24(10):773-8.
PMID: 26010430
Delayed wound healing is one of the major complications in diabetes and is characterized by chronic proinflammatory response, and abnormalities in angiogenesis and collagen deposition. Sirtuin family proteins regulate numerous...
7.
Brueggemann L, Mackie A, Cribbs L, Freda J, Tripathi A, Majetschak M, et al.
J Biol Chem
. 2013 Dec;
289(4):2099-111.
PMID: 24297175
The Kv7 family (Kv7.1-7.5) of voltage-activated potassium channels contributes to the maintenance of resting membrane potential in excitable cells. Previously, we provided pharmacological and electrophysiological evidence that Kv7.4 and Kv7.5...
8.
Mackie A, Krishnamurthy P, Verma S, Thorne T, Ramirez V, Qin G, et al.
J Biol Chem
. 2013 May;
288(25):18022-34.
PMID: 23645678
We have shown previously that estrogen (estradiol, E2) supplementation enhances voluntary alcohol consumption in ovariectomized female rodents and that increased alcohol consumption impairs ischemic hind limb vascular repair. However, the...
9.
Kishore R, Verma S, Mackie A, Vaughan E, Abramova T, Aiko I, et al.
PLoS One
. 2013 Apr;
8(4):e60161.
PMID: 23560074
Diabetes is associated with a higher incidence of myocardial infarction (MI) and increased risk for adverse vascular and fibrogenic events post-MI. Bone marrow-derived progenitor cell (BMPC) therapy has been shown...
10.
Thal M, Krishnamurthy P, Mackie A, Hoxha E, Lambers E, Verma S, et al.
Circ Res
. 2012 May;
111(2):180-90.
PMID: 22589372
Rationale: Although bone marrow endothelial progenitor cell (EPC)-based therapies improve the symptoms in patients with ischemic heart disease, their limited plasticity and decreased function in patients with existing heart disease...