Alexander Oksche
Overview
Explore the profile of Alexander Oksche including associated specialties, affiliations and a list of published articles.
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37
Citations
915
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Recent Articles
1.
Marz M, Himmelbauer M, Boldt K, Oksche A
GMS J Med Educ
. 2024 Oct;
41(4):Doc47.
PMID: 39415812
The high performance of generative artificial intelligence (AI) and large language models (LLM) in examination contexts has triggered an intense debate about their applications, effects and risks. What legal aspects...
2.
Nutrition Coverage in Medical Licensing Examinations in Germany: An Analysis of Six Nationwide Exams
Storz M, Oksche A, Schlasius-Ratter U, Schillings V, Beckschulte K, Huber R
Nutrients
. 2022 Dec;
14(24).
PMID: 36558492
The state of nutrition education in medicine is inadequate, with nutrition-related topics being poorly integrated into lectures. Most medical students receive only a few contact hours of nutrition instruction during...
3.
Rabiner E, Smith K, Bennett C, Rizzo G, Lewis Y, Mundin G, et al.
Br J Clin Pharmacol
. 2021 Jun;
88(4):1644-1654.
PMID: 34156715
Aims: Preclinical studies of MR309, a selective sigma-1 receptor (σ1R) antagonist, support a potential role in treating neuropathic pain. We report 2 studies that provide insight into the pharmacokinetics (PK)...
4.
Lyu S, DeAndrade M, Unger E, Mueller S, Oksche A, Walters A, et al.
J Neurosci Res
. 2020 May;
98(8):1532-1548.
PMID: 32424971
Restless legs syndrome (RLS) is characterized by an irresistible need to move the legs while sitting or lying at night with insomnia as a frequent consequence. Human RLS has been...
5.
Olofsen E, Boom M, Sarton E, van Velzen M, Baily P, Smith K, et al.
Anesthesiology
. 2019 Oct;
131(6):1327-1339.
PMID: 31651529
Background: There is an ongoing need for potent opioids with less adverse effects than commonly used opioids. R-dihydroetorphine is a full opioid receptor agonist with relatively high affinity at the...
6.
Wodehouse T, Demopoulos M, Petty R, Miraki-Moud F, Belhaj A, Husband M, et al.
Pain
. 2019 Aug;
160(12):2691-2698.
PMID: 31433352
Endogenous opioid peptides and exogenous opioids modulate immune function, and animal and human studies have shown that some have a depressant immunomodulatory effect. This is potentially of high clinical significance,...
7.
Lyu S, DeAndrade M, Mueller S, Oksche A, Walters A, Li Y
Behav Brain Res
. 2019 Aug;
374:112123.
PMID: 31376441
Previous studies have uncovered a potential role of the opioid system in iron hemostasis and dopamine metabolism. Abnormalities in both of these systems have been noted in human RLS. Autopsy...
8.
Serpell M, Tripathi S, Scherzinger S, Rojas-Farreras S, Oksche A, Wilson M
Patient
. 2015 Nov;
9(1):35-46.
PMID: 26547914
Background: Opioids provide effective analgesia for moderate-to-severe, chronic pain. Transdermal buprenorphine (TDB) is available in the UK as weekly, lower-dose (5-20 μg/h) patches and twice-weekly, higher dose (35-70 μg/h) patches....
9.
Trenkwalder C, Chaudhuri K, Martinez-Martin P, Rascol O, Ehret R, Valis M, et al.
Lancet Neurol
. 2015 Oct;
14(12):1161-70.
PMID: 26494524
Background: Pain is a common non-motor symptom of Parkinson's disease. We investigated the analgesic efficacy of prolonged-release oxycodone-naloxone (OXN PR) in patients with Parkinson's disease and chronic, severe pain. Methods:...
10.
Trenkwalder C, Benes H, Grote L, Garcia-Borreguero D, Hogl B, Hopp M, et al.
Lancet Neurol
. 2013 Oct;
12(12):1141-50.
PMID: 24140442
Background: Opioids are a potential new treatment for severe restless legs syndrome. We investigated the efficacy and safety of a fixed-dose combination of prolonged release oxycodone-naloxone for patients with severe...