Alexander M Owyang
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Explore the profile of Alexander M Owyang including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
560
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0
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Recent Articles
1.
Markovtsov V, Duncton M, Bagos A, Yi S, Braselmann S, Bhamidipati S, et al.
ACS Med Chem Lett
. 2023 Dec;
14(12):1700-1706.
PMID: 38116420
Dimethyl fumarate is approved for the treatment of multiple sclerosis but is also associated with off-target activation of the niacin receptor. By using a tetrazolone or triazolone bioisostere approach to...
2.
Haarberg K, Li J, Heinrichs J, Wang D, Liu C, Bronk C, et al.
Blood
. 2013 Aug;
122(14):2500-11.
PMID: 23908466
Allogeneic hematopoietic cell transplantation (HCT) is the most effective therapy for hematopoietic malignancies through T-cell-mediated graft-vs-leukemia (GVL) effects but often leads to severe graft-vs-host disease (GVHD). Given that protein kinase...
3.
Owyang A, Issafras H, Corbin J, Ahluwalia K, Larsen P, Pongo E, et al.
MAbs
. 2010 Nov;
3(1):49-60.
PMID: 21048425
Interleukin-1β (IL-1β) is a potent mediator of inflammatory responses and plays a role in the differentiation of a number of lymphoid cells. In several inflammatory and autoimmune diseases, serum levels...
4.
Roell M, Issafras H, Bauer R, Michelson K, Mendoza N, Vanegas S, et al.
J Biol Chem
. 2010 Apr;
285(27):20607-14.
PMID: 20410301
Many therapeutic antibodies act as antagonists to competitively block cellular signaling pathways. We describe here an approach for the therapeutic use of monoclonal antibodies based on context-dependent attenuation to reduce...
5.
Owyang A, Maedler K, Gross L, Yin J, Esposito L, Shu L, et al.
Endocrinology
. 2010 Mar;
151(6):2515-27.
PMID: 20332197
Recent evidence suggests that IL-1beta-mediated glucotoxicity plays a critical role in type 2 diabetes mellitus. Although previous work has shown that inhibiting IL-1beta can lead to improvements in glucose control...
6.
Kleinschek M, Owyang A, Joyce-Shaikh B, Langrish C, Chen Y, Gorman D, et al.
J Exp Med
. 2007 Jan;
204(1):161-70.
PMID: 17200411
Interleukin (IL)-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that...
7.
Owyang A, Zaph C, Wilson E, Guild K, Mcclanahan T, Miller H, et al.
J Exp Med
. 2006 Apr;
203(4):843-9.
PMID: 16606667
The cytokine interleukin (IL) 25 has been implicated in the initiation of type 2 immunity by driving the expression of type 2 cytokines such as IL-5 and IL-13, although its...
8.
Lieberman L, Cardillo F, Owyang A, Rennick D, Cua D, Kastelein R, et al.
J Immunol
. 2004 Jul;
173(3):1887-93.
PMID: 15265921
IL-23 and IL-12 are heterodimeric cytokines which share the p40 subunit, but which have unique second subunits, IL-23p19 and IL-12p35. Since p40 is required for the development of the Th1...
9.
Hsia C, Cheng S, Owyang A, Dowdy S, Liou H
Int Immunol
. 2002 Jul;
14(8):905-16.
PMID: 12147627
Surface-expressed BCR mediates the proliferation and expansion of antigen-specific B lymphocytes during a humoral immune response. Although several studies extensively characterize BCR proliferative signaling, the mechanisms linking these pathways to...