Alexander Kohlmann
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Explore the profile of Alexander Kohlmann including associated specialties, affiliations and a list of published articles.
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102
Citations
4679
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Recent Articles
1.
May T, Clement M, Halait H, Kohlmann A, Kohlmann M, Lai J, et al.
PLoS One
. 2024 Apr;
19(4):e0295987.
PMID: 38593164
Survival rates in non-small cell lung cancer (NSCLC) are low. Detection of circulating tumor DNA in liquid biopsy (plasma) is increasingly used to identify targeted therapies for clinically actionable mutations,...
2.
Gray J, Han J, Telaranta-Keerie A, Huang X, Kohlmann A, Hodge R, et al.
J Mol Diagn
. 2023 Nov;
26(1):73-84.
PMID: 37981090
Comprehensive genotyping is necessary to identify therapy options for patients with advanced cancer; however, many cancers are not tested, partly because of tissue limitations. Next-generation sequencing (NGS) liquid biopsies overcome...
3.
Hussain M, Corcoran C, Sibilla C, Fizazi K, Saad F, Shore N, et al.
Clin Cancer Res
. 2022 Jan;
28(8):1518-1530.
PMID: 35091440
Purpose: Successful implementation of genomic testing in clinical practice is critical for identification of men with metastatic castration-resistant prostate cancer (mCRPC) eligible for olaparib and future molecularly targeted therapies. Patients...
4.
Carter N, Clausen M, Halpin R, Blackmore C, Cai K, Delpuech O, et al.
Sci Rep
. 2021 Jun;
11(1):12676.
PMID: 34135391
Regular PCR testing of nasopharyngeal swabs from symptomatic individuals for SARS-CoV-2 virus has become the established method by which health services are managing the COVID-19 pandemic. Businesses such as AstraZeneca...
5.
de Bono J, Mateo J, Fizazi K, Saad F, Shore N, Sandhu S, et al.
N Engl J Med
. 2020 Apr;
382(22):2091-2102.
PMID: 32343890
Background: Multiple loss-of-function alterations in genes that are involved in DNA repair, including homologous recombination repair, are associated with response to poly(adenosine diphosphate-ribose) polymerase (PARP) inhibition in patients with prostate...
6.
Brown H, Vansteenkiste J, Nakagawa K, Cobo M, John T, Barker C, et al.
J Thorac Oncol
. 2019 Oct;
15(1):138-143.
PMID: 31605792
Introduction: EGFR mutated (EGFRm) NSCLC tumors occasionally express programmed cell death ligand 1 (PD-L1), although frequency and clinical relevance are not fully characterized. We report PD-L1 expression in patients with...
7.
Shumilov E, Flach J, Pabst T, Fiedler M, Angelillo-Scherrer A, Trumper L, et al.
Crit Rev Oncol Hematol
. 2018 May;
126:64-79.
PMID: 29759569
Owing to the introduction of next-generation sequencing (NGS) new challenges for diagnostic algorithms and the interpretation of the results for therapeutic decision making in hemato-oncology have arisen. Recurrent somatic mutations...
8.
Shumilov E, Flach J, Kohlmann A, Banz Y, Bonadies N, Fiedler M, et al.
Blood Rev
. 2018 May;
32(6):508-519.
PMID: 29728319
Diagnostics of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have recently been experiencing extensive modifications regarding the incorporation of next-generation sequencing (NGS) strategies into established diagnostic algorithms, classification and...
9.
Sherwood J, Brown H, Rettino A, Schreieck A, Clark G, Claes B, et al.
ESMO Open
. 2017 Oct;
2(4):e000235.
PMID: 29018576
Introduction: This study assessed mutation detection and functional characteristics across 13 distinct technologies and assays available in clinical practice, in a blinded manner. Methods: Five distinct -mutant cell lines were...
10.
Ellison G, Wallace A, Kohlmann A, Patton S
Br J Cancer
. 2017 Jul;
117(5):710-716.
PMID: 28751759
Background: Thousands of clinically relevant variations in BRCA1 and BRCA2 have been discovered and this poses a significant challenge with respect to the accurate detection, analysis turn-around time, characterisation and...