Alexander Kleger
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Explore the profile of Alexander Kleger including associated specialties, affiliations and a list of published articles.
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Articles
148
Citations
3354
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Recent Articles
1.
Schulte L, Schulte , Beck A, Marienfeld R, Azoitei N, Barth T, et al.
J Pathol
. 2025 Feb;
265(4):401-407.
PMID: 39906959
Pancreatic ductal adenocarcinoma (PDAC) often arises from preexisting cystic lesions such as intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN). This study investigated the molecular heterogeneity and mutational...
2.
Ibarguen-Gonzalez L, Heller S, Lopez-Garcia D, Dietenberger H, Barth T, Gallego P, et al.
Commun Med (Lond)
. 2025 Feb;
5(1):34.
PMID: 39900678
Background: Although COVID-19 initially caused great concern about respiratory symptoms, mounting evidence shows that also the pancreas is productively infected by SARS-CoV-2. However, the severity of pancreatic SARS-CoV-2 infection and...
3.
Lahusen A, Minhofer N, Lohse K, Blechner C, Lindenmayer J, Eiseler T, et al.
J Immunother Cancer
. 2025 Jan;
13(1.
PMID: 39824529
Background: Pancreatic ductal adenocarcinoma (PDAC) is mostly refractory to immunotherapy due to immunosuppression in the tumor microenvironment and cancer cell-intrinsic T cell tolerance mechanisms. PDAC is described as a "cold"...
4.
Beutel A, Ekizce M, Ettrich T, Seufferlein T, Lindenmayer J, Gout J, et al.
United European Gastroenterol J
. 2024 Nov;
13(1):21-33.
PMID: 39540683
Pancreatic ductal adenocarcinoma (PDAC) ranks among the leading causes of cancer-related deaths worldwide. Despite advances in precision oncology in other malignancies, treatment of PDAC still largely relies on conventional chemotherapy....
5.
Melzer M, Ma Y, Lindenmayer J, Morgenstern C, Wezel F, Zengerling F, et al.
Exp Hematol Oncol
. 2024 Nov;
13(1):112.
PMID: 39533373
Urothelial carcinoma (UC) of the urinary bladder has significant challenges in treatment due to its diverse genetic landscape and variable response to systemic therapy. In recent years, patient-derived organoids (PDOs)...
6.
Merz S, Senee V, Philippi A, Oswald F, Shaigan M, Fuhrer M, et al.
Cell Rep
. 2024 Oct;
43(11):114853.
PMID: 39427318
In a patient with permanent neonatal syndromic diabetes clinically similar to cases with ONECUT1 biallelic mutations, we identified a disease-causing deletion located upstream of ONECUT1. Through genetic, genomic, and functional...
7.
Liu J, Wang X, Jiang W, Azoitei A, Eiseler T, Eckstein M, et al.
Cell Mol Biol Lett
. 2024 Jul;
29(1):94.
PMID: 38956497
Background: We have previously identified an unsuspected role for GJB3 showing that the deficiency of this connexin protein induces aneuploidy in human and murine cells and accelerates cell transformation as...
8.
Fichtl A, Sheikhani A, Wagner M, Kleger A, Muller M, Sturm N, et al.
Sci Rep
. 2024 May;
14(1):10055.
PMID: 38698058
Endoscopic transgastric necrosectomy is crucial in the management of complications resulting from necrotizing pancreatitis. However, both real-time and visual-spatial information is lacking during the procedure, thereby jeopardizing a precise positioning...
9.
Lahusen A, Cai J, Schirmbeck R, Wellstein A, Kleger A, Seufferlein T, et al.
Sci Rep
. 2024 Apr;
14(1):9377.
PMID: 38654067
Poor treatment responses of pancreatic ductal adenocarcinoma (PDAC) are in large part due to tumor heterogeneity and an immunosuppressive desmoplastic tumor stroma that impacts interactions with cells in the tumor...
10.
Azoitei N, Heller S, Kleger A
Signal Transduct Target Ther
. 2024 Apr;
9(1):100.
PMID: 38627360
No abstract available.