Alexander Kleger
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Explore the profile of Alexander Kleger including associated specialties, affiliations and a list of published articles.
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148
Citations
3354
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Recent Articles
11.
Ruta V, Naro C, Pieraccioli M, Leccese A, Archibugi L, Cesari E, et al.
Cell Rep Med
. 2024 Feb;
5(2):101411.
PMID: 38325381
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extremely poor prognosis. PDAC presents with molecularly distinct subtypes, with the basal-like one being associated with enhanced chemoresistance. Splicing dysregulation contributes to PDAC;...
12.
Overbeek K, Poulsen J, Lanzillotta M, Vinge-Holmquist O, Macinga P, Demirci A, et al.
Clin Gastroenterol Hepatol
. 2024 Jan;
22(5):994-1004.e10.
PMID: 38184096
Background & Aims: Autoimmune pancreatitis (AIP) is an immune-mediated disease of the pancreas with distinct pathophysiology and manifestations. Our aims were to characterize type 1 AIP in a large pan-European...
13.
Perkhofer L, Kilani K, Wieser A, Seufferlein T, Kleger P, Mueller M, et al.
United European Gastroenterol J
. 2024 Jan;
12(1):159-161.
PMID: 38180459
No abstract available.
14.
Hafner S, Seufferlein T, Kleger A, Muller M
Z Gastroenterol
. 2023 Oct;
62(2):208-217.
PMID: 37827501
Aseptic liver abscesses occur very rarely. Clinical guidelines on the management of the disease do not exist, and the diagnosis is challenging.We screen MEDLINE and PUBMED databases for relevant case...
15.
Wang X, Liu J, Azoitei A, Eiseler T, Meessen S, Jiang W, et al.
Cell Mol Life Sci
. 2023 Sep;
80(10):299.
PMID: 37740130
We have recently shown that loss of ORP3 leads to aneuploidy induction and promotes tumor formation. However, the specific mechanisms by which ORP3 contributes to ploidy-control and cancer initiation and...
16.
Kruger J, Fischer A, Breunig M, Allgower C, Schulte L, Merkle J, et al.
J Pathol
. 2023 Aug;
261(2):139-155.
PMID: 37555362
Within the pancreas, Keratin 19 (KRT19) labels the ductal lineage and is a determinant of pancreatic ductal adenocarcinoma (PDAC). To investigate KRT19 expression dynamics, we developed a human pluripotent stem...
17.
Melzer M, Kleger A
Cell Stem Cell
. 2023 Aug;
30(8):1003-1005.
PMID: 37541205
In this issue, Jiang and colleagues employ multiple lineage-tracing approaches to elaborate on the role of Tff2+ transit-amplifying progenitor cells in the pancreatic acinar compartment of mice. This work provides...
18.
Mastracci T, Apte M, Amundadottir L, Alvarsson A, Artandi S, Bellin M, et al.
Diabetes
. 2023 Apr;
72(8):1173.
PMID: 37116182
No abstract available.
19.
Mastracci T, Apte M, Amundadottir L, Alvarsson A, Artandi S, Bellin M, et al.
Pancreas
. 2023 Apr;
51(9):1061-1073.
PMID: 37078927
The "Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases" Workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and...
20.
Merz S, Breunig M, Melzer M, Heller S, Wiedenmann S, Seufferlein T, et al.
Theranostics
. 2023 Apr;
13(6):1949-1973.
PMID: 37064874
Pancreatic lineage specification follows the formation of tripotent pancreatic progenitors (PPs). Current protocols rebuilding PPs have an endocrine lineage bias and are mostly based on PDX1/NKX6-1 coexpression neglecting other markers...