Alexander J Frey
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Explore the profile of Alexander J Frey including associated specialties, affiliations and a list of published articles.
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10
Citations
332
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Recent Articles
1.
Anderson S, Xu P, Frey A, Goodspeed J, Doan M, Orris J, et al.
Syst Biol Reprod Med
. 2021 Dec;
68(1):36-43.
PMID: 34962441
Cumulus cell (CC) clumps that associate with oocytes provide the oocytes with growth and signaling factors. Thus, the metabolism of the CCs may influence oocyte function, and CC metabolism may...
2.
Terloyeva D, Frey A, Park B, Kauffman E, Mathew L, Bostwick A, et al.
Mol Autism
. 2020 Nov;
11(1):93.
PMID: 33228808
Background: Prenatal exposure to increased androgens has been suggested as a risk factor for autism spectrum disorder (ASD). This hypothesis has been examined by measurement of steroids in amniotic fluid,...
3.
Liu J, Zhao R, Ye Z, Frey A, Schriver E, Snyder N, et al.
J Steroid Biochem Mol Biol
. 2017 Sep;
174:169-175.
PMID: 28867356
Human cytosolic sulfotransferase 1A1 (SULT1A1) is considered to be one of the most important SULT isoforms for metabolism, detoxification, and carcinogenesis. This theory is driven by observations that SULT1A1 is...
4.
Frey A, Park B, Schriver E, Feldman D, Parry S, Croen L, et al.
J Steroid Biochem Mol Biol
. 2016 Nov;
167:78-85.
PMID: 27871978
Prenatal metabolism exerts profound effects on development. The first stool of the newborn, meconium, provides a window into the prenatal metabolic environment. The objective of this study was to examine...
5.
Frey A, Wang Q, Busch C, Feldman D, Bottalico L, Mesaros C, et al.
Steroids
. 2016 Nov;
116:60-66.
PMID: 27743906
A multiplexed quantitative method for the analysis of three major unconjugated steroids in human serum by stable isotope dilution liquid chromatography-high resolution mass spectrometry (LC-HRMS) was developed and validated on...
6.
Zhao S, Torres A, Henry R, Trefely S, Wallace M, Lee J, et al.
Cell Rep
. 2016 Oct;
17(4):1037-1052.
PMID: 27760311
Mechanisms of metabolic flexibility enable cells to survive under stressful conditions and can thwart therapeutic responses. Acetyl-coenzyme A (CoA) plays central roles in energy production, lipid metabolism, and epigenomic modifications....
7.
Frey A, Feldman D, Trefely S, Worth A, Basu S, Snyder N
Anal Bioanal Chem
. 2016 Mar;
408(13):3651-8.
PMID: 26968563
Acyl-coenzyme A (acyl-CoA) thioesters are evolutionarily conserved, compartmentalized, and energetically activated substrates for biochemical reactions. The ubiquitous involvement of acyl-CoA thioesters in metabolism, including the tricarboxylic acid cycle, fatty acid...
8.
Frey A, Ibrahim S, Gleim S, Hwa J, Smyth E
J Lipid Res
. 2013 Mar;
54(6):1678-1690.
PMID: 23493750
Thromboxane A2 (TXA2) contributes to cardiovascular disease (CVD) by activating platelets and vascular constriction and proliferation. Despite their preclinical efficacy, pharmacological antagonists of the TXA2 receptor (TP), a G protein-coupled...
9.
Park J, Mangal D, Frey A, Harvey R, Blair I, Penning T
J Biol Chem
. 2009 Sep;
284(43):29725-34.
PMID: 19726680
Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by aldo-keto reductases are ligands for the aryl hydrocarbon receptor (AhR) (Burczynski, M. E., and Penning, T. M. (2000) Cancer Res. 60, 908-915). They...
10.
Wilson S, Cavanagh C, Lesher A, Frey A, Russell S, Smyth E
J Lipid Res
. 2009 Jan;
50(6):1047-56.
PMID: 19151335
Thromboxane A(2) (TxA(2)), the principle product of platelet COX-1-dependent arachidonic acid metabolism, directs multiple pro-atherogenic processes via its receptor, TP. Oxidative challenge offsets TP degradation, a key component in limiting...