Alexander G Dossetter
Overview
Explore the profile of Alexander G Dossetter including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
129
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0
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Recent Articles
1.
Thompson S, Buckl A, Dossetter A, Griffen E, Gill A
Expert Opin Ther Pat
. 2021 Jul;
31(12):1189-1204.
PMID: 34253125
Up to 30% of all human cancers are driven by the overactivation of RAS signaling. Son of Sevenless 1 (SOS1) is a central node in RAS signaling pathways and modulation...
2.
Zarnecka J, Lukac I, Messham S, Hussin A, Coppola F, Enoch S, et al.
J Chem Inf Model
. 2021 Mar;
61(4):1859-1874.
PMID: 33755448
Many of the recently developed methods to study the shape of molecules permit one conformation of one molecule to be compared to another conformation of the same or a different...
3.
Griffen E, Dossetter A, Leach A
J Med Chem
. 2020 May;
63(16):8695-8704.
PMID: 32459965
The latest developments in artificial intelligence (AI) have arrived into an existing state of creative tension between computational and medicinal chemists. At their most productive, medicinal and computational chemists have...
4.
Griffen E, Dossetter A, Leach A, Montague S
Drug Discov Today
. 2018 Mar;
23(7):1373-1384.
PMID: 29577971
AI comes to lead optimization: medicinal chemistry in all disease areas can be accelerated by exploiting our pre-competitive knowledge in an unbiased way.
5.
Lukac I, Zarnecka J, Griffen E, Dossetter A, St-Gallay S, Enoch S, et al.
J Chem Inf Model
. 2017 Oct;
57(10):2424-2436.
PMID: 28967750
We have applied the two most commonly used methods for automatic matched pair identification, obtained the optimum settings, and discovered that the two methods are synergistic. A turbocharging approach to...
6.
Colley H, Muthana M, Danson S, Jackson L, Brett M, Harrison J, et al.
J Med Chem
. 2015 Nov;
58(23):9309-33.
PMID: 26580420
A number of indole-3-glyoxylamides have previously been reported as tubulin polymerization inhibitors, although none has yet been successfully developed clinically. We report here a new series of related compounds, modified...
7.
McCoull W, Barton P, Brown A, Bowker S, Cameron J, Clarke D, et al.
J Med Chem
. 2014 Jun;
57(14):6128-40.
PMID: 24967667
Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by...
8.
Goldberg F, Dossetter A, Scott J, Robb G, Boyd S, Groombridge S, et al.
J Med Chem
. 2014 Jan;
57(3):970-86.
PMID: 24422550
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been widely considered by the pharmaceutical industry as a target to treat metabolic syndrome in type II diabetics. We hypothesized that central nervous system...
9.
Dossetter A, Griffen E, Leach A
Drug Discov Today
. 2013 Apr;
18(15-16):724-31.
PMID: 23557664
Multiple parameter optimisation in drug discovery is difficult, but Matched Molecular Pair Analysis (MMPA) can help. Computer algorithms can process data in an unbiased way to yield design rules and...
10.
Crawford J, Kenny P, Bowyer J, Cook C, Finlayson J, Heyes C, et al.
J Med Chem
. 2012 Sep;
55(20):8827-37.
PMID: 22984809
Rational structure-based design has yielded highly potent inhibitors of cathepsin K (Cat K) with excellent physical properties, selectivity profiles, and pharmacokinetics. Compounds with a 3,4-(CH₃O)₂Ph motif, such as 31, were...