Alexander Ehrmann
Overview
Explore the profile of Alexander Ehrmann including associated specialties, affiliations and a list of published articles.
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8
Citations
215
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0
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Recent Articles
1.
Li H, Pike A, Chang Y, Prakaash D, Gelova Z, Stanka J, et al.
Nat Commun
. 2025 Jan;
16(1):721.
PMID: 39820269
Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects....
2.
Digles D, Ingles-Prieto A, Dvorak V, Mocking T, Goldmann U, Garofoli A, et al.
Front Pharmacol
. 2024 Jul;
15:1401599.
PMID: 39050757
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with...
3.
Unterschemmann K, Ehrmann A, Herzig I, Andreevski A, Lustig K, Schmeck C, et al.
Am J Physiol Renal Physiol
. 2020 Nov;
320(1):F61-F73.
PMID: 33196323
Oxidative stress is a key concept in basic, translational, and clinical research to understand the pathophysiology of various disorders, including cardiovascular and renal diseases. Although attempts to directly reduce oxidative...
4.
Superti-Furga G, Lackner D, Wiedmer T, Ingles-Prieto A, Barbosa B, Girardi E, et al.
Nat Rev Drug Discov
. 2020 Apr;
19(7):429-430.
PMID: 32265506
No abstract available.
5.
Fleming J, Schupfner M, Busch F, Basle A, Ehrmann A, Sterner R, et al.
J Mol Biol
. 2018 Oct;
430(24):5066-5079.
PMID: 30367843
Tryptophan synthase (TrpS) is a heterotetrameric αββα enzyme that exhibits complex substrate channeling and allosteric mechanisms and is a model system in enzymology. In this work, we characterize proposed early...
6.
Kovalenko I, Glasauer A, Schockel L, Sauter D, Ehrmann A, Sohler F, et al.
PLoS One
. 2016 Aug;
11(8):e0160658.
PMID: 27494181
Pancreatic ductal adenocarcinoma (PDAC) represents the most common form of pancreatic cancer with rising incidence in developing countries and overall 5-year survival rates of less than 5%. The most frequent...
7.
Ellinghaus P, Heisler I, Unterschemmann K, Haerter M, Beck H, Greschat S, et al.
Cancer Med
. 2014 Jan;
2(5):611-24.
PMID: 24403227
The activation of the transcription factor hypoxia-inducible factor-1 (HIF-1) plays an essential role in tumor development, tumor progression, and resistance to chemo- and radiotherapy. In order to identify compounds targeting...
8.
Ehrmann A, Richter K, Busch F, Reimann J, Albers S, Sterner R
Biochemistry
. 2010 Nov;
49(51):10842-53.
PMID: 21090805
The prototypical tryptophan synthases form a stable heterotetrameric αββα complex in which the constituting TrpA and TrpB1 subunits activate each other in a bidirectional manner. The hyperthermophilic archaeon Sulfolobus solfataricus...
9.
Wunschmann J, Krajewski M, Letzel T, Huber E, Ehrmann A, Grill E, et al.
Phytochemistry
. 2009 Nov;
71(1):54-61.
PMID: 19897216
Xenobiotics are widely used as pesticides. The detoxification of xenobiotics frequently involves conjugation to glutathione prior to compartmentalization and catabolism. In plants, degradation of glutathione-S-conjugates is initiated either by aminoterminal...