Alexander C Zambon
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Explore the profile of Alexander C Zambon including associated specialties, affiliations and a list of published articles.
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43
Citations
1776
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Recent Articles
1.
Cao S, Buchholz K, Tan P, Stowe J, Wang A, Fowler A, et al.
Am J Physiol Heart Circ Physiol
. 2023 Dec;
326(2):H370-H384.
PMID: 38063811
To identify how cardiomyocyte mechanosensitive signaling pathways are regulated by anisotropic stretch, micropatterned mouse neonatal cardiomyocytes were stretched primarily longitudinally or transversely to the myofiber axis. Four hours of static,...
2.
Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice
Castellanos D, Sun J, Yang J, Ou W, Zambon A, Pardridge W, et al.
Pharmaceutics
. 2020 Sep;
12(9).
PMID: 32911688
Non-invasive brain delivery of neurotherapeutics is challenging due to the blood-brain barrier. The revived interest in transferrin receptor antibodies (TfRMAbs) as brain drug-delivery vectors has revealed the effect of dosing...
3.
Zambon A, Hsu T, Kim S, Klinck M, Stowe J, Henderson L, et al.
Physiol Genomics
. 2020 Sep;
52(10):468-477.
PMID: 32866086
Much of our understanding of the regulatory mechanisms governing the cell cycle in mammals has relied heavily on methods that measure the aggregate state of a population of cells. While...
4.
Hsu T, Mallareddy J, Yoshida K, Bustamante V, Lee T, Krstenansky J, et al.
Pharmacol Res Perspect
. 2019 Aug;
7(5):e00511.
PMID: 31463067
Opioids are powerful analgesics acting via the human μ-opiate receptor (hMOR). Opioid use is associated with adverse effects such as tolerance, addiction, respiratory depression, and constipation. Two synthetic opioids, AH-7921...
5.
Walker J, Zhuang H, Singer D, Illsley C, Kok W, Sivaraj K, et al.
Nat Commun
. 2019 Aug;
10(1):3596.
PMID: 31399601
Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse...
6.
Neri T, Hiriart E, van Vliet P, Faure E, Norris R, Farhat B, et al.
Nat Commun
. 2019 Apr;
10(1):1929.
PMID: 31028265
Genetically modified mice have advanced our understanding of valve development and disease. Yet, human pathophysiological valvulogenesis remains poorly understood. Here we report that, by combining single cell sequencing and in...
7.
Singer D, Thamm K, Zhuang H, Karbanova J, Gao Y, Walker J, et al.
EMBO J
. 2018 Dec;
38(2).
PMID: 30523147
Proper temporal and spatial activation of stem cells relies on highly coordinated cell signaling. The primary cilium is the sensory organelle that is responsible for transmitting extracellular signals into a...
8.
Chang R, Castillo J, Zambon A, Krasieva T, Fisher M, Sumbria R
Front Cell Neurosci
. 2018 Sep;
12:279.
PMID: 30237761
Peripheral endothelial cells are capable of erythrophagocytosis, but data on brain endothelial erythrophagocytosis are limited. We studied the relationship between brain endothelial erythrophagocytosis and cerebral microhemorrhage, the pathological substrate of...
9.
Gan Z, Powell F, Zambon A, Buchholz K, Fu Z, Ocorr K, et al.
J Physiol
. 2017 Jul;
595(17):5797-5813.
PMID: 28688178
Key Points: Changes in gene expression that occur within hours of exposure to hypoxia in in vivo skeletal muscles remain unexplored. Two hours of hypoxia caused significant down-regulation of extracellular...
10.
Blice-Baum A, Zambon A, Kaushik G, Viswanathan M, Engler A, Bodmer R, et al.
Aging Cell
. 2017 Jan;
16(1):93-103.
PMID: 28090761
Heart performance declines with age. Impaired protein quality control (PQC), due to reduced ubiquitin-proteasome system (UPS) activity, autophagic function, and/or chaperone-mediated protein refolding, contributes to cardiac deterioration. The transcription factor...