Alexander Alanine
Overview
Explore the profile of Alexander Alanine including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
249
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0
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Recent Articles
1.
Zampaloni C, Mattei P, Bleicher K, Winther L, Thate C, Bucher C, et al.
Nature
. 2024 Jul;
631(8022):E17.
PMID: 38992182
No abstract available.
2.
Zampaloni C, Mattei P, Bleicher K, Winther L, Thate C, Bucher C, et al.
Nature
. 2024 Jan;
625(7995):566-571.
PMID: 38172634
Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options. No new antibiotic chemical class with activity against A. baumannii has reached patients in over...
3.
Wlodek A, Kendrew S, Coates N, Hold A, Pogwizd J, Rudder S, et al.
Nat Commun
. 2017 Nov;
8(1):1206.
PMID: 29089518
Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an assembly-line process in which each module of enzymes in turn specifies attachment...
4.
Webber M, Warren S, Grainger D, Weston M, Clark S, Woodhead S, et al.
Org Biomol Chem
. 2013 Feb;
11(15):2514-33.
PMID: 23443742
The development of a stereoselective total synthesis of β-dihydroagarofuran 4 is described. This compound contains the same oxygenation pattern on its 'lower-rim' as found in the natural sesquiterpene (-)-euonyminol (1)...
5.
Pinard E, Alanine A, Alberati D, Bender M, Borroni E, Bourdeaux P, et al.
J Med Chem
. 2010 May;
53(12):4603-14.
PMID: 20491477
The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia. Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine class of GlyT1 inhibitors to improve...
6.
Peters J, Lubbers T, Alanine A, Kolczewski S, Blasco F, Steward L
Bioorg Med Chem Lett
. 2007 Nov;
18(1):262-6.
PMID: 18023344
The optimisation of molecular properties within a series of 2-amino dihydroquinazoline 5-HT5A/5-HT7 receptor ligands resulted in a significantly improved brain-to-plasma ratio, enhancing the pharmacological utility of these compounds. By modulating...
7.
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation
Peters J, Lubbers T, Alanine A, Kolczewski S, Blasco F, Steward L
Bioorg Med Chem Lett
. 2007 Nov;
18(1):256-61.
PMID: 17998160
The optimisation of affinity and selectivity in a novel series of dual 5-HT5A/5-HT7 receptor ligands is described. Brain penetrant 2-aminodihydroquinazolines with low nanomolar affinities were identified.
8.
Woltering T, Adam G, Alanine A, Wichmann J, Knoflach F, Mutel V, et al.
Bioorg Med Chem Lett
. 2007 Oct;
17(24):6811-5.
PMID: 17964783
A series of 1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Attachment of an 8-(2-aryl)-ethynyl-moiety produced compounds inhibiting the binding of [(3)H]-LY354740 to rat mGluR2 with low nanomolar affinity and...
9.
Alanine A, Anselm L, Steward L, Thomi S, Vifian W, Groaning M
Bioorg Med Chem Lett
. 2004 Jan;
14(3):817-21.
PMID: 14741297
The synthesis and in vitro structure-activity relationships (SAR) of a series of triazoles as A(2A) receptor antagonists is reported. This resulted in the identification of potent, selective and permeable 1,2,4-triazoles...
10.
Alanine A, Bourson A, Buttelmann B, Gill R, Heitz M, Mutel V, et al.
Bioorg Med Chem Lett
. 2003 Sep;
13(19):3155-9.
PMID: 12951084
Screening of the Roche compound depository led to the identification of (1-benzyloxy-4,5-dihydro-1H-imidazol-2-yl)-butyl amine 4, a structurally novel NR1/2B subtype selective NMDA receptor antagonist. The structure-activity relationships developed in this series...