Alexander Adibekian
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Explore the profile of Alexander Adibekian including associated specialties, affiliations and a list of published articles.
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78
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1787
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Recent Articles
1.
Racioppo B, Pechalrieu D, Abegg D, Dwyer B, Ramseier N, Hu Y, et al.
J Am Chem Soc
. 2025 Feb;
147(9):7817-7828.
PMID: 39989026
Proteolysis targeting chimeras (PROTACs) represent powerful tools to modulate the activity of classically "undruggable" proteins, but their application has been limited to known ligands and a few select protein classes....
2.
Bennett J, Narwal S, Kabeche S, Abegg D, Thathy V, Hackett F, et al.
Cell Chem Biol
. 2024 Aug;
31(9):1714-1728.e10.
PMID: 39137783
Malaria, caused by Plasmodium falciparum, remains a significant health burden. One major barrier for developing antimalarial drugs is the ability of the parasite to rapidly generate resistance. We previously demonstrated...
3.
Qiu N, Pechalrieu D, Abegg D, Adibekian A
Chem Res Toxicol
. 2024 Mar;
37(4):620-632.
PMID: 38484110
As a vital micronutrient, zinc is integral to the structure, function, and signaling networks of diverse proteins. Dysregulated zinc levels, due to either excess intake or deficiency, are associated with...
4.
Bennett J, Narwal S, Kabeche S, Abegg D, Hackett F, Yeo T, et al.
bioRxiv
. 2024 Jan;
PMID: 38260474
Malaria, caused by remains a significant health burden. A barrier for developing anti-malarial drugs is the ability of the parasite to rapidly generate resistance. We demonstrated that Salinipostin A (SalA),...
5.
Tong Y, Zhang P, Yang X, Liu X, Zhang J, Grudniewska M, et al.
Proc Natl Acad Sci U S A
. 2024 Jan;
121(2):e2306682120.
PMID: 38181056
α-Synuclein is an important drug target for the treatment of Parkinson's disease (PD), but it is an intrinsically disordered protein lacking typical small-molecule binding pockets. In contrast, the encoding mRNA...
6.
Morstein J, Amatuni A, Shuster A, Kuttenlochner W, Ko T, Abegg D, et al.
Angew Chem Int Ed Engl
. 2023 Dec;
63(8):e202314791.
PMID: 38109686
Photolipids have emerged as attractive tools for the optical control of lipid functions. They often contain an azobenzene photoswitch that imparts a cis double-bond upon irradiation. Herein, we present the...
7.
Suresh B, Tong Y, Abegg D, Adibekian A, Childs-Disney J, Disney M
ACS Chem Biol
. 2023 Oct;
18(11):2385-2393.
PMID: 37824291
Small molecules that target RNA and effect their cleavage are useful chemical probes and potential lead medicines. In this study, we investigate factors affecting degradation of two cancer-associated RNA targets,...
8.
Tong Y, Lee Y, Liu X, Childs-Disney J, Suresh B, Benhamou R, et al.
Nature
. 2023 May;
618(7963):169-179.
PMID: 37225982
Target occupancy is often insufficient to elicit biological activity, particularly for RNA, compounded by the longstanding challenges surrounding the molecular recognition of RNA structures by small molecules. Here we studied...
9.
Yang Y, Jung Y, Abegg D, Adibekian A, Carroll K, Karbstein K
Mol Cell
. 2023 Apr;
83(9):1527-1537.e5.
PMID: 37086725
Because of the central role ribosomes play for protein translation and ribosome-mediated mRNA and protein quality control (RQC), the ribosome pool is surveyed and dysfunctional ribosomes degraded both during assembly,...
10.
Tong Y, Gibaut Q, Rouse W, Childs-Disney J, Suresh B, Abegg D, et al.
J Am Chem Soc
. 2023 Apr;
145(16):9364.
PMID: 37058601
No abstract available.