Alex W Jacobitz
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Explore the profile of Alex W Jacobitz including associated specialties, affiliations and a list of published articles.
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10
Citations
184
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Recent Articles
1.
Liu S, Humphreys S, Cook K, Conner K, Correia A, Jacobitz A, et al.
MAbs
. 2023 Oct;
15(1):2263926.
PMID: 37824334
In this investigation, we tested the hypothesis that a physiologically based pharmacokinetic (PBPK) model incorporating measured metrics of off-target binding can largely explain the inter-antibody variability in monoclonal antibody (mAb)...
2.
Mock M, Jacobitz A, Langmead C, Sudom A, Yoo D, Humphreys S, et al.
MAbs
. 2023 Sep;
15(1):2256745.
PMID: 37698932
Biologic drug discovery pipelines are designed to deliver protein therapeutics that have exquisite functional potency and selectivity while also manifesting biophysical characteristics suitable for manufacturing, storage, and convenient administration to...
3.
Jacobitz A, Liu Q, Suravajjala S, Agrawal N
J Pharm Sci
. 2020 Nov;
110(2):719-726.
PMID: 33198947
Tryptophan oxidation can play an important role in selecting therapeutic monoclonal antibodies for commercialization. Monoclonal antibodies that harbor particularly sensitive tryptophan residues are typically discarded in favor of oxidation resistant...
4.
Effects of Buffer Composition on Site-Specific Glycation of Lysine Residues in Monoclonal Antibodies
Jacobitz A, Dykstra A, Spahr C, Agrawal N
J Pharm Sci
. 2019 Jun;
109(1):293-300.
PMID: 31150698
Candidate antibodies under consideration for development as pharmaceuticals must be screened for potential liabilities. Glycation of lysine side chains is one liability which can significantly alter the efficacy of a...
5.
Jacobitz A, Kattke M, Wereszczynski J, Clubb R
Adv Protein Chem Struct Biol
. 2017 Jul;
109:223-264.
PMID: 28683919
Gram-positive bacteria use sortase cysteine transpeptidase enzymes to covalently attach proteins to their cell wall and to assemble pili. In pathogenic bacteria sortases are potential drug targets, as many of...
6.
Jacobitz A, Naziga E, Yi S, McConnell S, Peterson R, Jung M, et al.
J Phys Chem B
. 2016 Apr;
120(33):8302-12.
PMID: 27109553
Many species of Gram-positive bacteria use sortase enzymes to assemble long, proteinaceous pili structures that project from the cell surface to mediate microbial adhesion. Sortases construct highly stable structures by...
7.
Amer B, Macdonald R, Jacobitz A, Liauw B, Clubb R
J Biomol NMR
. 2016 Feb;
64(3):197-205.
PMID: 26852413
Many proteins can't be studied using solution NMR methods because they have limited solubility. To overcome this problem, recalcitrant proteins can be fused to a more soluble protein that functions...
8.
Jacobitz A, Wereszczynski J, Yi S, Amer B, Huang G, Nguyen A, et al.
J Biol Chem
. 2014 Feb;
289(13):8891-902.
PMID: 24519933
Sortase cysteine transpeptidases covalently attach proteins to the bacterial cell wall or assemble fiber-like pili that promote bacterial adhesion. Members of this enzyme superfamily are widely distributed in Gram-positive bacteria...
9.
Robson S, Jacobitz A, Phillips M, Clubb R
Biochemistry
. 2012 Sep;
51(40):7953-63.
PMID: 22974341
Bacillus anthracis forms metabolically dormant endospores that upon germination can cause lethal anthrax disease in humans. Efficient sporulation requires the activity of the SrtC sortase (BaSrtC), a cysteine transpeptidase that...
10.
King N, Jacobitz A, Sawaya M, Goldschmidt L, Yeates T
Proc Natl Acad Sci U S A
. 2010 Nov;
107(48):20732-7.
PMID: 21068371
A very small number of natural proteins have folded configurations in which the polypeptide backbone is knotted. Relatively little is known about the folding energy landscapes of such proteins, or...