Alex von Kriegsheim
Overview
Explore the profile of Alex von Kriegsheim including associated specialties, affiliations and a list of published articles.
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Articles
116
Citations
2711
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Recent Articles
1.
ODonoghue L, Hiebner D, Krishnankutty R, Schoen I, von Kriegsheim A, Smolenski A
Cell Signal
. 2024 Dec;
127:111568.
PMID: 39689749
Hypochlorous acid (HOCl), made by neutrophil-derived myeloperoxidase, has been suggested to inhibit platelets, however, the mechanisms involved have not been described. Here we confirm that HOCl exposure changes platelet morphology...
2.
Lu Y, Travnickova J, Badonyi M, Rambow F, Coates A, Khan Z, et al.
Cell Rep
. 2024 Nov;
43(11):114927.
PMID: 39546399
No abstract available.
3.
Mihalikova D, Stamm P, Kvandova M, Pednekar C, Strohm L, Ubbens H, et al.
Eur J Prev Cardiol
. 2024 Oct;
PMID: 39351780
Background: Epidemiology links noise to increased risk of metabolic diseases like diabetes and obesity. Translational studies in humans and experimental animals showed that noise causes reactive oxygen species (ROS)-mediated cardiovascular...
4.
Churchhouse A, Billard C, Suzuki T, Pohl S, Doleschall N, Donnelly K, et al.
Oncogene
. 2024 Sep;
43(42):3094-3107.
PMID: 39242821
Inflammatory Bowel Disease-associated colorectal cancer (IBD-CRC) is a known and serious complication of Inflammatory Bowel Disease (IBD) affecting the colon. However, relatively little is known about the pathogenesis of IBD-associated...
5.
Makar A, Boraman A, Mosen P, Simpson J, Marques J, Michelberger T, et al.
Nat Commun
. 2024 Sep;
15(1):7743.
PMID: 39231962
Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. Using a CRISPR/Cas9-based...
6.
Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James S, et al.
Leukemia
. 2024 Aug;
38(11):2395-2409.
PMID: 39187579
Identification of specific and therapeutically actionable vulnerabilities, ideally present across multiple mutational backgrounds, is needed to improve acute myeloid leukemia (AML) patients' outcomes. We identify stearoyl-CoA desaturase (SCD), the key...
7.
Carrasco G, Stavrou I, Treanor-Taylor M, Beetham H, Lee M, Masalmeh R, et al.
Oncogenesis
. 2024 Jul;
13(1):24.
PMID: 38982038
Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1, the gene that encodes Kindlin-1. KS patients have a high propensity to develop aggressive and metastatic cutaneous...
8.
Lu Y, Travnickova J, Badonyi M, Rambow F, Coates A, Khan Z, et al.
Cell Rep
. 2024 Jul;
43(7):114406.
PMID: 38963759
Cancer cellular heterogeneity and therapy resistance arise substantially from metabolic and transcriptional adaptations, but how these are interconnected is poorly understood. Here, we show that, in melanoma, the cancer stem...
9.
Gutierrez E, Mitchell S, Hambly C, Sayle K, von Kriegsheim A, Speakman J, et al.
iScience
. 2024 Jul;
27(6):110059.
PMID: 38947513
This study characterized the effect of calorie restriction (CR) on elemental content and stable isotope ratio measurements of bone "collagen" and hair keratin. Adult mice on graded CR (10-40%; 84 ...
10.
Megaw R, Moye A, Zhang Z, Newton F, McPhie F, Murphy L, et al.
Nat Commun
. 2024 May;
15(1):4316.
PMID: 38773095
As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter membrane shape. Photoreceptor outer segments comprise an expanse of folded...