Alex R D Delbridge
Overview
Explore the profile of Alex R D Delbridge including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
774
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Recent Articles
1.
Delbridge A, Huh D, Brickelmaier M, Burns J, Roberts C, Challa R, et al.
Front Cell Neurosci
. 2021 Jan;
14:592005.
PMID: 33473245
Microglia are central nervous system (CNS) resident immune cells that have been implicated in neuroinflammatory pathogenesis of a variety of neurological conditions. Their manifold context-dependent contributions to neuroinflammation are only...
2.
Delbridge A, Kueh A, Ke F, Zamudio N, El-Saafin F, Jansz N, et al.
Cell Rep
. 2019 Apr;
27(2):442-454.e5.
PMID: 30970248
Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete penetrance. We found...
3.
Ke F, Vanyai H, Cowan A, Delbridge A, Whitehead L, Grabow S, et al.
Cell
. 2018 May;
173(5):1217-1230.e17.
PMID: 29775594
Intrinsic apoptosis, reliant on BAX and BAK, has been postulated to be fundamental for morphogenesis, but its precise contribution to this process has not been fully explored in mammals. Our...
4.
Delbridge A, Pang S, Vandenberg C, Grabow S, Aubrey B, Tai L, et al.
J Exp Med
. 2016 Sep;
213(10):2039-48.
PMID: 27621418
Neoplastic transformation is driven by oncogenic lesions that facilitate unrestrained cell expansion and resistance to antiproliferative signals. These oncogenic DNA lesions, acquired through errors in DNA replication, gene recombination, or...
5.
Delbridge A, Chappaz S, Ritchie M, Kile B, Strasser A, Grabow S
Br J Haematol
. 2016 May;
174(6):962-9.
PMID: 27221652
Apoptosis is required to maintain tissue homeostasis in multicellular organisms. Platelets, the anucleate cells that are essential for blood clotting, are a prime example. Their brief life span in the...
6.
Grabow S, Delbridge A, Aubrey B, Vandenberg C, Strasser A
Cell Rep
. 2016 Mar;
14(10):2337-47.
PMID: 26947081
MCL-1 is critical for progenitor cell survival during emergency hematopoiesis, but its role in sustaining cells undergoing transformation and in lymphomagenesis is only poorly understood. We investigated the importance of...
7.
Delbridge A, Grabow S, Strasser A, Vaux D
Nat Rev Cancer
. 2016 Jan;
16(2):99-109.
PMID: 26822577
The 'hallmarks of cancer' are generally accepted as a set of genetic and epigenetic alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows...
8.
Delbridge A, Opferman J, Grabow S, Strasser A
Blood
. 2015 Apr;
125(21):3273-80.
PMID: 25847014
Understanding the critical factors that govern recovery of the hematopoietic system from stress, such as during anticancer therapy and bone marrow transplantation, is of clinical significance. We investigated the importance...
9.
Grabow S, Delbridge A, Valente L, Strasser A
Blood
. 2014 Nov;
124(26):3939-46.
PMID: 25368374
Apoptosis plays a role in normal lymphopoiesis and lymphoid malignancies. Pro-survival MCL-1 is essential for survival of T-cell progenitors, BCL-XL for immature thymocytes, and BCL-2 for mature T cells. Conversely,...
10.
Delbridge A, Valente L, Strasser A
Cold Spring Harb Perspect Biol
. 2012 Nov;
4(11).
PMID: 23125015
Multicellular organisms have evolved processes to prevent abnormal proliferation or inappropriate tissue infiltration of cells, and these tumor suppressive mechanisms serve to prevent tissue hyperplasia, tumor development, and metastatic spread...