Alex Kong
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Explore the profile of Alex Kong including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
459
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Recent Articles
1.
McCaffrey E, Delmastro A, Fitzhugh I, Ranek J, Douglas S, Peters J, et al.
bioRxiv
. 2025 Mar;
PMID: 40027668
Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to (Mtb) infection and support bacterial persistence. We previously discovered that human TB granulomas are...
2.
Greenwald N, Nederlof I, Sowers C, Ding D, Park S, Kong A, et al.
bioRxiv
. 2025 Feb;
PMID: 39975273
Immune checkpoint inhibition (ICI) has fundamentally changed cancer treatment. However, only a minority of patients with metastatic triple negative breast cancer (TNBC) benefit from ICI, and the determinants of response...
3.
Rumberger J, Greenwald N, Ranek J, Boonrat P, Walker C, Franzen J, et al.
bioRxiv
. 2024 Jun;
PMID: 38895405
Multiplexed imaging offers a powerful approach to characterize the spatial topography of tissues in both health and disease. To analyze such data, the specific combination of markers that are present...
4.
Piyadasa H, Oberlton B, Kong A, Fullaway C, Varra S, Sowers C, et al.
J Vis Exp
. 2023 Oct;
(199).
PMID: 37782085
Multiplexed ion beam imaging (MIBI) is a next-generation mass spectrometry-based microscopy technique that generates 40+ plex images of protein expression in histologic tissues, enabling detailed dissection of cellular phenotypes and...
5.
Liu C, Greenwald N, Kong A, McCaffrey E, Leow K, Mrdjen D, et al.
Nat Commun
. 2023 Aug;
14(1):4618.
PMID: 37528072
While technologies for multiplexed imaging have provided an unprecedented understanding of tissue composition in health and disease, interpreting this data remains a significant computational challenge. To understand the spatial organization...
6.
Wallis T, Welham B, Kong A, Morelli T, Azim A, Horno J, et al.
Respir Res
. 2022 Nov;
23(1):297.
PMID: 36316730
Background: Routine follow-up of patients hospitalised with COVID-19 is recommended, however due to the ongoing high number of infections this is not without significant health resource and economic burden. In...
7.
Liu C, Bosse M, Kong A, Kagel A, Kinders R, Hewitt S, et al.
Lab Invest
. 2022 Mar;
102(7):762-770.
PMID: 35351966
Multiplexed ion beam imaging by time-of-flight (MIBI-TOF) is a form of mass spectrometry imaging that uses metal labeled antibodies and secondary ion mass spectrometry to image dozens of proteins simultaneously...
8.
Risom T, Glass D, Averbukh I, Liu C, Baranski A, Kagel A, et al.
Cell
. 2022 Jan;
185(2):299-310.e18.
PMID: 35063072
Ductal carcinoma in situ (DCIS) is a pre-invasive lesion that is thought to be a precursor to invasive breast cancer (IBC). To understand the changes in the tumor microenvironment (TME)...
9.
Greenwald N, Miller G, Moen E, Kong A, Kagel A, Dougherty T, et al.
Nat Biotechnol
. 2021 Nov;
40(4):555-565.
PMID: 34795433
A principal challenge in the analysis of tissue imaging data is cell segmentation-the task of identifying the precise boundary of every cell in an image. To address this problem we...
10.
Avila C, Willins J, Jackson M, Mathai J, Jabsky M, Kong A, et al.
Am J Perinatol
. 2015 May;
32(11):1001-9.
PMID: 26007317
Objective: To assess the usefulness of two definitions of acute clinical chorioamnionitis (ACCA) in predicting risk of neonatal infectious outcomes (NIO) and mortality, the first definition requiring maternal fever alone...