Alex J Fulcher
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Explore the profile of Alex J Fulcher including associated specialties, affiliations and a list of published articles.
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25
Citations
471
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Recent Articles
1.
Uckelmann M, Levina V, Taveneau C, Ng X, Pandey V, Martinez J, et al.
Nat Struct Mol Biol
. 2025 Jan;
PMID: 39815045
The compaction of chromatin is a prevalent paradigm in gene repression. Chromatin compaction is commonly thought to repress transcription by restricting chromatin accessibility. However, the spatial organization and dynamics of...
2.
Malhotra A, Dehghankelishadi P, Kaur I, Marshall M, Rudd D, Wojnilowicz M, et al.
ACS Appl Mater Interfaces
. 2025 Jan;
17(4):5955-5969.
PMID: 39804251
Common treatment approaches for triple-negative breast cancer (TNBC) are associated with severe side effects due to the unfavorable biodistribution profile of potent chemotherapeutics. Here, we explored the potential of TNBC-targeting...
3.
Obeng E, Steer D, Fulcher A, Wagstaff K
Nanoscale Adv
. 2023 Apr;
5(8):2251-2260.
PMID: 37056610
Exploitation of the biotin-streptavidin interaction for advanced protein engineering is used in many bio-nanotechnology applications. As such, researchers have used diverse techniques involving chemical and enzyme reactions to conjugate biotin...
4.
Obeng E, Fulcher A, Wagstaff K
Biotechnol Adv
. 2023 Feb;
64:108108.
PMID: 36740026
The engineering of potent prophylactic and therapeutic complexes has always required careful protein modification techniques with seamless capabilities. In this light, methods that favor unobstructed multivalent targeting and correct antigen...
5.
Payne J, Kulkarni K, Izore T, Fulcher A, Peleg A, Aguilar M, et al.
Nanoscale Adv
. 2022 Sep;
3(9):2607-2616.
PMID: 36134162
The increasing resistance of pathogenic microbes to antimicrobials and the shortage of antibiotic drug discovery programs threaten the clinical use of antibiotics. This threat calls for the development of new...
6.
Payne J, Tailhades J, Ellett F, Kostoulias X, Fulcher A, Fu T, et al.
Nat Commun
. 2021 Oct;
12(1):6157.
PMID: 34697316
The pathogen Staphylococcus aureus can readily develop antibiotic resistance and evade the human immune system, which is associated with reduced levels of neutrophil recruitment. Here, we present a class of...
7.
Zareie P, Szeto C, Farenc C, Gunasinghe S, Kolawole E, Nguyen A, et al.
Science
. 2021 Jun;
372(6546).
PMID: 34083463
T cell receptor (TCR) recognition of peptide-major histocompatibility complexes (pMHCs) is characterized by a highly conserved docking polarity. Whether this polarity is driven by recognition or signaling constraints remains unclear....
8.
Conduit S, Davies E, Fulcher A, Oorschot V, Mitchell C
Front Cell Dev Biol
. 2021 May;
9:634649.
PMID: 33996795
Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment...
9.
Azad M, Zhang S, Li J, Kim Y, Yu H, Fulcher A, et al.
Antimicrob Agents Chemother
. 2021 Mar;
65(5).
PMID: 33649114
Intravenous administration of the last-line polymyxins results in poor drug exposure in the lungs and potential nephrotoxicity; while inhalation therapy offers better pharmacokinetics/pharmacodynamics for pulmonary infections by delivering the antibiotic...
10.
Kulkarni K, Hung J, Fulcher A, Chan A, Hong A, Forsythe J, et al.
ACS Biomater Sci Eng
. 2021 Jan;
4(11):3843-3847.
PMID: 33429591
β-peptides uniquely form shear thinning hydrogels which are proteolytically stable and biocompatible. Herein we describe the synthesis, material and optical characterization of a new class of fluorescently labeled hydrogelators based...