Alex E Lash
Overview
Explore the profile of Alex E Lash including associated specialties, affiliations and a list of published articles.
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13
Citations
11102
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Recent Articles
1.
Buja A, Volfovsky N, Krieger A, Lord C, Lash A, Wigler M, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(8):E1859-E1866.
PMID: 29434036
In individuals with autism spectrum disorder (ASD), de novo mutations have previously been shown to be significantly correlated with lower IQ but not with the core characteristics of ASD: deficits...
2.
Pietanza M, Hellmann M, Fiore J, Smith-Marrone S, Basch E, Schwartz L, et al.
J Thorac Oncol
. 2016 Mar;
11(6):890-9.
PMID: 26964771
Introduction: Many patients with lung cancers cannot receive platinum-containing regimens owing to comorbid medical conditions. We designed the PPB (paclitaxel, pemetrexed, and bevacizumab) regimen to maintain or improve outcomes while...
3.
Baugh E, Simmons-Edler R, Muller C, Alford R, Volfovsky N, Lash A, et al.
Nucleic Acids Res
. 2016 Mar;
44(6):2501-13.
PMID: 26926108
Existing methods for interpreting protein variation focus on annotating mutation pathogenicity rather than detailed interpretation of variant deleteriousness and frequently use only sequence-based or structure-based information. We present VIPUR, a...
4.
Wiesner T, Obenauf A, Murali R, Fried I, Griewank K, Ulz P, et al.
Nat Genet
. 2011 Aug;
43(10):1018-21.
PMID: 21874003
Common acquired melanocytic nevi are benign neoplasms that are composed of small, uniform melanocytes and are typically present as flat or slightly elevated pigmented lesions on the skin. We describe...
5.
Taylor B, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver B, et al.
Cancer Cell
. 2010 Jun;
18(1):11-22.
PMID: 20579941
Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in...
6.
Girard N, Shen R, Guo T, Zakowski M, Heguy A, Riely G, et al.
Clin Cancer Res
. 2009 Oct;
15(22):6790-9.
PMID: 19861435
Purpose: Thymomas and thymic carcinomas are rare intrathoracic malignancies that can be invasive and refractory to conventional treatment. Because these tumors both originate from the thymus, they are often grouped...
7.
Guha U, Chaerkady R, Marimuthu A, Scott Patterson A, Kashyap M, Harsha H, et al.
Proc Natl Acad Sci U S A
. 2008 Sep;
105(37):14112-7.
PMID: 18776048
We have used unbiased phosphoproteomic approaches, based on quantitative mass spectrometry using stable isotope labeling with amino acids in cell culture (SILAC), to identify tyrosine phosphorylated proteins in isogenic human...
8.
Marks J, McLellan M, Zakowski M, Lash A, Kasai Y, Broderick S, et al.
PLoS One
. 2007 May;
2(5):e426.
PMID: 17487277
Background: Fifty percent of lung adenocarcinomas harbor somatic mutations in six genes that encode proteins in the EGFR signaling pathway, i.e., EGFR, HER2/ERBB2, HER4/ERBB4, PIK3CA, BRAF, and KRAS. We performed...
9.
Higgins M, Claremont M, Major J, Sander C, Lash A
Nucleic Acids Res
. 2006 Nov;
35(Database issue):D721-6.
PMID: 17088289
The genome sequence framework provided by the human genome project allows us to precisely map human genetic variations in order to study their association with disease and their direct effects...
10.
Barrett T, Suzek T, Troup D, Wilhite S, Ngau W, Ledoux P, et al.
Nucleic Acids Res
. 2004 Dec;
33(Database issue):D562-6.
PMID: 15608262
The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) is the largest fully public repository for high-throughput molecular abundance data, primarily gene expression data. The database...