Alex Avdeef
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Explore the profile of Alex Avdeef including associated specialties, affiliations and a list of published articles.
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75
Citations
1295
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Recent Articles
21.
Fuguet E, Subirats X, Rafols C, Bosch E, Avdeef A
Mol Pharm
. 2021 May;
18(6):2311-2321.
PMID: 33983741
It is widely accepted that solubility-pH profiles of ionizable compounds follow the Henderson-Hasselbalch equation. However, several studies point out that compounds often undergo additional processes in saturated solutions, such as...
22.
Llinas A, Oprisiu I, Avdeef A
J Chem Inf Model
. 2020 Aug;
60(10):4791-4803.
PMID: 32794744
Ten years ago, we issued an open prediction challenge to the cheminformatics community: would participants be able to predict the equilibrium intrinsic solubilities of 32 druglike molecules using only a...
23.
Avdeef A, Kansy M
Mol Pharm
. 2020 Aug;
17(10):3930-3940.
PMID: 32787270
This study describes a novel nonlinear variant of the well-known Yalkowsky general solubility equation (GSE). The modified equation can be trained with small molecules, mostly from the Lipinski Rule of...
24.
Di L, Artursson P, Avdeef A, Benet L, Houston J, Kansy M, et al.
ChemMedChem
. 2020 Aug;
15(20):1862-1874.
PMID: 32743945
Passive permeability is a key property in drug disposition and delivery. It is critical for gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance mechanisms and drug-drug interactions. Passive diffusion rate...
25.
Lucero-Borja D, Subirats X, Barbas R, Prohens R, Avdeef A, Rafols C
Eur J Pharm Sci
. 2020 Mar;
148:105305.
PMID: 32184154
The solubility of three drugs (glimepiride, pioglitazone, sibutramine) with different acid/base properties and expected supersaturation behavior was examined in detail using the shake-flask (SF) and potentiometric (CheqSol) methods. Both uncharged...
26.
Llinas A, Avdeef A
J Chem Inf Model
. 2019 May;
59(6):3036-3040.
PMID: 31042031
Ten years ago we issued, in conjunction with the Journal of Chemical Information and Modeling, an open prediction challenge to the cheminformatics community. Would they be able to predict the...
27.
Markovic O, Pesic M, Shah A, Serajuddin A, Verbic T, Avdeef A
Eur J Pharm Sci
. 2019 Mar;
133:264-274.
PMID: 30914359
Although solubility-pH data for desipramine hydrochloride (DsHCl) have been reported previously, the aim of the present study was to critically examine the aqueous solubility-pH behavior of DsHCl in buffer-free and...
28.
Avdeef A
Pharm Res
. 2018 Feb;
35(2):40.
PMID: 29396647
Purpose: To predict the aqueous solubility product (K ) and the solubility enhancement of cocrystals (CCs), using an approach based on measured drug and coformer intrinsic solubility (S , S...
29.
Lozoya-Agullo I, Gonzalez-Alvarez I, Zur M, Fine-Shamir N, Cohen Y, Markovic M, et al.
Pharm Res
. 2017 Dec;
35(1):2.
PMID: 29288412
Purpose: The effective rat intestinal permeability (P ) was deconvolved using a biophysical model based on parameterized paracellular, aqueous boundary layer, transcellular permeabilities, and the villus-fold surface area expansion factor....
30.
Yusof S, Abbott N, Avdeef A
Eur J Pharm Sci
. 2017 Jun;
106:274-286.
PMID: 28614733
Most studies of blood-brain barrier (BBB) permeability and transport are conducted at a single pH, but more detailed information can be revealed by using multiple pH values. A pH-dependent biophysical...